Clinical Trial of L. Reuteri in Infantile Colic 2017

Inclusion Criteria:

• Younger than 10 weeks of age

• Full term infant (37-42 weeks gestational age)

• Birth weight ≥ 2,500g

• Apgar score ≥ 7 at 5 minutes

• Infantile colic diagnosed according to modified Wessel's criteria (crying more than 180 min/day during 3 days for at least a week prior to enrolment)

• Parental motivation to postpone changes in the infant feeding mode, unless necessary

• Stated availability throughout the study period

• Parent(s) willingness and ability to fill out charts and questionnaires

• Signed informed consent

Exclusion Criteria:

• Failure to thrive

• Chronic illness or major medical problem

• Gastrointestinal disease

• Use of any antibiotic 2 weeks before Day 1 in the study. This applies also tolactating mothers whose infants participate in the trial

• Use of supplements/eaten foods that contain Lactobacillus reuteri, 2 weeks before Day 1

• Use of proton pump inhibitors in the week (7 days) prior to enrolment

• If breastfeeding, use of probiotic by the mother in the week (7 days) prior toenrolment and throughout the study period

• Use of infant formula with hydrolysed protein

• Infant receiving solid foods (such as cereals, mashed fruits or vegetable purée)

• Change of feeding mode planned by parents during the study period