Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight

Inclusion Criteria:

• Informed consent obtained before any study-related activities. Study-relatedactivities are any procedures that are carried out as part of the study, includingactivities to determine suitability for the study.

• Female or male (sex at birth).

• Age 18 years or above at the time of signing the informed consent.

• Body mass index (BMI) of

1. ≥ 27.0 kilogram per square meter (kg/m^2) with the presence of at least oneweight-related comorbidity including, but not limited to, hypertension,dyslipidaemia, obstructive sleep apnoea or CV disease.OR

2. ≥ 30.0 kg/m^2.

• History of at least one self-reported unsuccessful dietary effort to lose bodyweight.

Exclusion Criteria:

• A self-reported change in body weight greater than (>) 5% within 90 days beforescreening irrespective of medical records.

• HbA1c ≥ 6.5% (48 millimoles per mole [mmol/mol]) as measured by the centrallaboratory at screening.

• Consistent use of glucagon like peptide-1 (GLP-1) receptor agonists, includingmedication with glucagon like peptide-1 receptor agonist (GLP-1 RA) activity likedual GLP-1/gastric inhibitory peptide RAs, or amylin analogues before screening.Consistent use is defined as treatment.