A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows

Inclusion Criteria:

• Participant should be male or female, ≥18 years of age at the time of signing theinformed consent.

• Moderate or severe (Grade 2 or 3) GL at MF at baseline, as assessed by the ILA usinga validated 4-point photographic scale.

• Moderate or severe (Grade 2 or 3) GL at MF at baseline, as assessed by the SSA usinga 4-point categorical scale.

• Are 'dissatisfied' or 'very dissatisfied' with their GLs at baseline, as assessed bythe SLS score.

• For female participants: Contraceptive use by women should be consistent with localregulations regarding the methods of contraception for those participating inclinical studies.

• Capable of giving signed informed consent which includes compliance with therequirements and restrictions listed in the ICF and in this protocol.

• Participant has both the time and ability to complete the study and comply withstudy instructions.

• Does not reside in an institution by administrative or court order.

• Is not a sponsor employee or clinical research unit personnel directly affiliatedwith the study or is not an immediate family member. Immediate family is defined asa spouse, parent, child or sibling whether biological or legally adopted.

Exclusion Criteria:

• An active infection or other skin problems in the upper face including the GL area (e.g. acute acne lesions or ulcers).

• A history of eyelid blepharoplasty or brow lift or any other upper facial surgerywithin the past 5 years.

• A history of facial nerve palsy.

• Marked facial asymmetry, ptosis, excessive dermatochalasis, deep dermal scarring orthick sebaceous skin.

• Closed-angle glaucoma or a predisposition to it (for Japan only).

• Any known medical condition that may put the participant at increased risk withregard to exposure to BoNT of any serotype (i.e. myasthenia gravis, Eaton-Lambertsyndrome, amyotrophic lateral sclerosis, etc.).

• Presence of any scars, piercings, or tattoos (including microblading of theeyebrows) in or around the treatment area that have occurred within 6 months priorto baseline, or which in the investigator's opinion, could interfere withevaluations.

• Administration of any BoNT (other than the study intervention) into any site of thebody and for any indication from 9 months prior to the first study visit until theend of the study.

• Treatment with IPN10200 in any prior study.

• Use of medications that affect neuromuscular transmission (such as curare-likenondepolarising agents, lincosamides, polymyxins, anticholinesterases) within thepast 30 days prior to baseline is prohibited or a longer washout period of at leastfive half lives might be required, as deemed appropriate by the investigator forlong-acting medications.

• Use of aminoglycoside antibiotics within the past 30 days prior to baseline areprohibited. Note: Topical use apart from the area of injection would be acceptable.

• Use of systemic retinoids within the past 30 days prior to baseline and planned useduring the study. Note: Topical retinoids are allowed other than in the areas thatwill be injected (upper facial area) at the discretion of the investigator.

• Any prior treatment with permanent fillers, lifting threads, autologous fat orpermanent procedures in the upper face including the GL area.

• Administration of any nonpermanent injectables (such as hyaluronic acid, calciumhydroxylapatite, poly-L-lactic acid or polymethyl-methacrylate) for soft tissueaugmentation therapy in the GL region within 12 months prior to baseline.

• Any prior facial treatment or aesthetic procedures to the upper face includingphotorejuvenation, vascular or pigment laser or microneedling within the 3 monthsprior to baseline.

• Any prior facial treatment or aesthetic procedures to the upper face involving skinresurfacing (including dermabrasion, laser, or whatever the interventional techniqueused) or chemical peel within the past 12 months prior to baseline.

• Any planned cosmetic surgery or aesthetic procedures to the upper face during thestudy and/or any procedures to other parts of the face which in the investigator'sopinion, could interfere with evaluations during the study.

• Any past surgery in the upper facial line area including GL.

• Planned use of concomitant therapy which, in the investigator's opinion, wouldinterfere with the evaluation of the safety or efficacy of the study intervention.Therapy considered necessary for the participant's welfare may be given at thediscretion of the investigator. Note: If the permissibility of a specificmedication/treatment is in question, the medical monitor will be contacted.

• Use of any experimental device within 30 days or use of any treatment with anexperimental drug within five times the documented terminal half-life of therespective drug or its metabolites or if the half-life is unknown within 30 daysprior to the start of the study (prior to baseline) and during the conduct of thestudy.

• Known positive for hepatitis B antigen, or hepatitis C virus antibody, or for humanimmunodeficiency virus or a diagnosis of acquired immunodeficiency syndrome.

• Clinically diagnosed significant anxiety disorder, or any other significantpsychiatric disorder (e.g. depression) that might interfere with the participant'sparticipation in the study.

• An inability to substantially lessen GL as determined by the investigator.

• Known allergy or hypersensitivity to BoNT or any excipients of IPN10200.

• A history of chronic or recreational drug abuse as assessed by the investigator.

• Any uncontrolled systemic disease or other significant medical condition which wouldbe harmful for the participant to be entered into the study or continueparticipation.