A Research Study on How Well Different Doses of the Medicine UBT251 Help People Living With Overweight or Obesity

Last updated: April 20, 2026
Sponsor: Novo Nordisk A/S
Overall Status: Active - Recruiting

Phase

2

Condition

Obesity

Diabetes Prevention

Hypertriglyceridemia

Treatment

UBT251

Placebo

Clinical Study ID

NCT07395687
NN9559-8568
U1111-1324-3831
  • Ages 18-65
  • All Genders

Study Summary

The purpose of this clinical study is to find out if UBT251 is safe and effective for treating people who are living with overweight or obesity. Participants will get either UBT251 (the treatment being tested) or Placebo (a treatment that has no active medicine in it), which treatment participants get is decided by chance.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Male or female (sex at birth).

  2. For Part C: Japanese, Chinese or non-Asian participants (all self-reported):

  • For Japanese participants: both parents of Japanese descent.

  • For Chinese participants: both parents of Chinese descent.

  • For non-Asian participants: both parents of non-Asian descent (non-Asian isdefined as of countries outside of Asia).

  1. Age at the time of signing the informed consent:

  2. For Part A: 18-55 years (both inclusive)

  3. For Part B: 18-65 years (both inclusive)

  4. For Part C: 18-55 years (both inclusive).

  5. BMI at screening (overweight and obesity should be due to excess adipose tissue, asjudged by the investigator):

  6. For Part A: 27.0-39.9 kilogram per meter square (kg/m^2) (both inclusive)

  7. For Part B: 30.0-50.0 kg/m^2 (both inclusive)

  8. For Part C: 24-34.9 kg/m^2 (both inclusive)

  9. Considered eligible based on the medical history, physical examination, and theresults of vital signs, electrocardiogram (ECG), and clinical laboratory testsperformed during the screening visit, as judged by the investigator.

Exclusion

Exclusion Criteria:

  1. Known or suspected hypersensitivity to study intervention(s) or related products.

  2. Treatment with any marketed product containing compounds with glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) or glucagon receptoragonism within 90 days before screening.

  3. Any condition, unwillingness or inability, which in the investigator's opinion mightjeopardise the participant's safety or compliance with the protocol.

Study Design

Total Participants: 333
Treatment Group(s): 2
Primary Treatment: UBT251
Phase: 2
Study Start date:
February 02, 2026
Estimated Completion Date:
February 18, 2027

Connect with a study center

  • Altasciences Clinical Company, Inc

    Montreal, Quebec H3P 3P1
    Canada

    Active - Recruiting

  • Altasciences Clinical Company, Inc

    Montreal 6077243, Quebec 6115047 H3P 3P1
    Canada

    Site Not Available

  • Altasciences Clinical LA, Inc.

    Cypress, California 90630
    United States

    Active - Recruiting

  • Altasciences Clinical LA, Inc.

    Cypress 5341256, California 5332921 90630
    United States

    Site Not Available

  • Altasciences Clinical Kansas, Inc.

    Overland Park, Kansas 66212
    United States

    Active - Recruiting

  • Altasciences Clinical Kansas, Inc.

    Overland Park 4276873, Kansas 4273857 66212
    United States

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.