Phase Ⅲ Study of Efficacy and Safety of HSK39297 Tablet in Treatment of Patients With Primary IgAN

Inclusion Criteria:

1. Subjects must have signed and dated an IRB/IEC approved written informed consentform.Subjects must be willing and able to comply with scheduled visits, treatmentschedule, laboratory tests, tumor biopsies, and other requirements of the study.

2. Female and male patients above 18 years of age.

3. Patients must weigh at least 35 kg to participate in the study, and must have a bodymass index (BMI) below 35 kg/m2. BMI = Body weight (kg) / [Height (m)]2

4. Subjects with a biopsy-verified IgA nephropathy and where the biopsy was performedwithin the prior ten years.

5. 24h-UPCR ≥0.75g/g or 24h-UPE≥1.0g/24h at screening.

6. Measured Glomerular Filtration Rate (GFR) or estimated GFR (using the CKD-EPIformula 2021) ≥30 mL/min per 1.73 m2.For patients with eGFR* 20 to <30ml/min/1.73m2,a qualifying biopsy performed in two years.

Exclusion Criteria:

1. Use of other investigational drugs at the time of enrollment, or within 5 half-livesof enrollment, or within 90 days, whichever is longer.

2. All transplanted patients (any organ, including bone marrow).

3. History of malignancy of any organ system (other than localized basal cell carcinomaof the skin or in-situ cervical cancer).

4. Any surgical or medical condition which might significantly alter the absorption,distribution, metabolism, or excretion of drugs, or which may jeopardize the subjectin case of participation in the study.

5. Pregnant or nursing (lactating) women.

6. Plasma donation (≥ 400mL) within 12 weeks prior to first dosing.