A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight

Inclusion Criteria:

• Have a Body Mass Index (BMI) at screening

• ≥ 30 kilogram per square meter (kg/m2) OR

• ≥ 27 kg/m2 with presence of at least one of the following weight-relatedconditions at screening: high blood pressure, abnormal levels of lipid,obstructive sleep apnea, heart disease

• Have at least one unsuccessful attempt to lose weight by dieting

Exclusion Criteria:

• Have a self-reported change in body weight >5 kilograms (kg) (11 pounds) within 90days before screening

• Have a prior or planned surgical treatment for obesity

• Have type 1 diabetes or type 2 diabetes

• Have a family or personal history of medullary thyroid carcinoma (MTC) or multipleendocrine neoplasia syndrome type 2 (MEN-2)

• Have had within the past 90 days before screening:

• heart attack

• stroke

• hospitalization for unstable angina or heart failure

• Have New York Heart Association Functional Classification Class IV congestive heartfailure

• Have a history of chronic or acute pancreatitis

• Have taken weight loss drugs, including over-the counter medications within 90 daysprior to screening