AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

Key Inclusion Criteria:

• Male or female (sex at birth).

• Informed consent obtained before any study-related activities. Study-relatedactivities are any procedures that are carried out as part of the study, includingactivities to determine suitability for the study.

• History of at least one self-reported unsuccessful dietary effort to lose bodyweight.

Key Exclusion Criteria:

• HbA1c ≥ 6.5% (48 millimole per mole [mmol/mol]) as measured by the centrallaboratory at screening.

• History of type 1 or type 2 diabetes mellitus as declared by the participant orreported in the medical records.

• Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dualGLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) oramylin analogues before screening.