Correlation Between Advanced Glycation End Products and Gastric Motility Disorder in Diabetes Gastroparesis

Phase

N/A

Condition

Gastroparesis

Diabetic Gastroparesis

Treatment

N/A

Clinical Study ID

NCT07324785

2025ky077

Ages 18-75
All Genders

Study Summary

This study is a prospective observational study. The study will explore the correlation between advanced glycation end products and gastric motility disorder in diabetic gastroparesis（DGP) through the collection of blood and gastric tissue samples and relevant data of patients with DGP and control group patients without diabetes history and gastroparesis symptoms.

Eligibility Criteria

Inclusion

Inclusion Criteria for diabetes gastroparesis group:

Meet the diagnostic criteria for diabetes
Presence of symptoms (see assessment of Gastroparesis Cardinal Symptom Index)
Age range from 18 to 75 years old
Voluntarily participate and sign an informed consent form

Inclusion Criteria for control group:

No history of diabetes
No symptoms (see assessment of Gastroparesis Cardinal Symptom Index)
Age range from 18 to 75 years old
Voluntarily participate and sign an informed consent form

Exclusion Criteria for diabetes gastroparesis group and control group:

Currently taking prokinetic drugs, anticholinergic drugs, and dopamine drugs that may affect gastric motility
Has a history of gastrointestinal surgery
Pregnant or preparing to conceive
There are neurological disorders such as Parkinson's disease that affect gastrointestinal function
Outlet obstruction caused by organic lesions in the pylorus

Study Design

January 07, 2026

May 31, 2027

Study Description

This study will collect the gastric smooth muscle tissue and serum of patients with diabetic gastroparesis（DGP) and control group patients without diabetes history and gastroparesis symptoms, and collect the following patient related information: age, gender, height, weight, fasting blood glucose, diabetes course, glycosylated hemoglobin, fasting C-peptide, serum creatinine, and electrogastrogram results.

The study will compare the score of gastroparesis cardinal symptom index scale and electrogastrogram results of patients with DGP and and control group patients without diabetes history and gastroparesis symptoms, detect and compare the difference in the expression of contractile protein in the muscle layer of gastric tissue of the two groups, detect and compare the difference in advanced glycation end products (AGEs) of serum and gastric tissue of the two groups, and analyze the correlation between serum and gastric tissue AGEs and clinical symptoms. Through the above results, we will clarify the correlation between AGEs and gastric motility disorders in DGP.

Connect with a study center

Northern Jiangsu People's Hospital
Yangzhou 1787227, Jiangsu 1806260 225001
China
Active - Recruiting

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