Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease

Last updated: January 3, 2026
Sponsor: Shanghai University of Sport
Overall Status: Active - Recruiting

Phase

N/A

Condition

Parkinson's Disease

Dyskinesias

Treatment

Transcranial Temporal Interference Stimulation (TIS)

Clinical Study ID

NCT07309198
102772024RT146
  • Ages 50-80
  • All Genders

Study Summary

The goal of this clinical trial is to learn whether a type of brain stimulation called transcranial temporal interference stimulation (TIS) of the internal globus pallidus (GPi) can help improve movement symptoms in people with Parkinson's disease. The study will also look at how TIS changes brain activity related to these improvements.

The main questions this study aims to answer are:

  • How much can repeated TIS sessions improve movement symptoms in people with Parkinson's disease?

  • Can these improvements last for up to two months after the treatment ends?

  • What changes in brain activity happen along with the improvements?

Researchers will compare people who receive active TIS with those who receive sham (placebo-like) stimulation to see whether active TIS leads to better movement outcomes.

Participants will:

  • Receive 10 sessions of active or sham TIS over two weeks

  • Complete movement assessments during the two-week treatment and again 2, 4, and 8 weeks afterward

  • Complete brain activity assessments before and after the two-week treatment

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • A physician-diagnosed idiopathic Parkinson's disease (PD) according to the MovementDisorder Society (MDS) diagnostic criteria, with onset after the age of 40.

  • Stable antiparkinsonian medication regimen, including levodopa-containing therapy,unchanged for at least 4 weeks before and during the trial.

  • Hoehn and Yahr (H&Y) stages 1.5 to 3 and ability to walk unassisted.

  • Absence of dementia, defined as a Montreal Cognitive Assessment (MoCA) score ≥ 21.

Exclusion

Exclusion Criteria:

  • Any contraindication for MRI or transcranial temporal interference stimulation (TIS), including claustrophobia, metallic implants in the head or heart, or ahistory of electroconvulsive therapy.

  • Current use of antipsychotic, antidepressant, or other dopamine-modulatingmedications.

  • Presence of orthopedic conditions that may interfere with motor assessments, such asosteoarthritis or recent orthopedic surgery (within the past 6 months).

  • History of physician-diagnosed major psychiatric illness.

  • Physician-diagnosed cardiovascular risks that could contraindicate exercise or studyparticipation.

  • Prior history of deep brain stimulation (DBS) surgery.

Study Design

Total Participants: 36
Treatment Group(s): 1
Primary Treatment: Transcranial Temporal Interference Stimulation (TIS)
Phase:
Study Start date:
December 29, 2025
Estimated Completion Date:
June 01, 2026

Connect with a study center

  • Shanghai University of Sport

    Shanghai 1796236, Shanghai Municipality 1796231 200438
    China

    Active - Recruiting

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