Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial

Inclusion Criteria:

• Age 35 to ≤ 80 years.

• Lp(a) ≥ 200 nmol/L during screening.

• Angiographic evidence of coronary artery disease in at least one major epicardialvessel on screening CCTA.

• History of myocardial infarction (presumed type 1 event due to plaquerupture/erosion) and/or coronary revascularization by percutaneous coronaryintervention.

Exclusion Criteria:

• History of coronary artery bypass graft (CABG).

• Moderate to severe renal dysfunction.

• Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 x upper limitof normal (ULN), or total bilirubin (TBL) > 2 x ULN during screening.

• History of hemorrhagic stroke.

• History of major bleeding disorder.

• Planned cardiac surgery or arterial revascularization.

• Severe heart failure.

• Current, recent, or planned lipoprotein apheresis.

• Previously received ribonucleic acid therapy specifically targeting Lp(a).