Metabolomic Profiling of Patients With Traumatic Brain Injury

Last updated: December 17, 2025
Sponsor: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Memory Loss

Traumatic Brain Injury

Treatment

N/A

Clinical Study ID

NCT07292766
TBI_omics
  • Ages 18-65
  • All Genders

Study Summary

Traumatic Brain Injury (TBI) is a significant cause of mortality and morbidity worldwide. However, the literature on determining its severity and predicting prognosis is insufficient. This study aimed to examine the differences in metabolite levels between trauma patients with severe TBI and orthopedic trauma patients without brain injury.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Ages 18-65

  • Patients diagnosed with severe TBI clinically or according to National Institute forHealth and Care Excellence (NICE) criteria (including post-traumatic imaging)

  • Patients with non-TBI orthopedic or multitrauma

Exclusion

Exclusion Criteria:

  • Presence of brain pathology in the pre-trauma period

  • Patient with chronic subdural hematoma

Study Design

Total Participants: 60
Study Start date:
February 01, 2024
Estimated Completion Date:
February 01, 2026

Study Description

Traumatic Brain Injury (TBI) is a significant cause of mortality and morbidity worldwide, particularly in young people. TBI is a complex metabolic process associated with an energy crisis resulting from multiple mechanisms, including ischemia, diffusion hypoxia, and mitochondrial dysfunction. Because metabolic derangement is a fundamental component of TBI pathophysiology, these metabolic changes may provide prognostic information and guide treatment. Additionally, the release of brain-specific metabolites (i.e., small molecules with a molecular mass below 500 Da) into the systemic circulation may provide insights into blood-brain barrier (BBB) dysfunction, a fundamental process in TBI. Metabolomic profiling studies are introductory and valuable for elucidating this metabolic process.

Connect with a study center

  • Aksaray University

    Aksaray, Ankara 323784 06810
    Turkey (Türkiye)

    Active - Recruiting

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