A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain

Inclusion Criteria:

• Have presence of diabetic peripheral neuropathy, of symmetrical nature and in lowerextremities for ≥6 months and diagnosed by a score of Part B ≥3 on MichiganNeuropathy Screening Instrument (©University of Michigan)

• Have a history and current diagnosis of type 1 or type 2 diabetes mellitus.

• Have an HbA1c <11% and on a stable regimen for treatment of diabetes at least 90days prior to screening

• Have a body mass index at screening of ≤40 kilogram per meter squared (kg/m2)

Exclusion Criteria:

• Are pregnant or breastfeeding

• Have a history of other potentially causative and/or confounding sources of painthat may impair self-assessment of pain due to diabetic peripheral neuropathic pain (DPNP)

• Have lower limb amputation due to diabetes inclusive of great toe (metatarsal bone)

• Have serum vitamin B12 ≤200 picogram per milliliter (pg/mL)

• Have an abnormal BP (systolic BP >140 mm Hg and diastolic BP>90 mm Hg) at screening

• Have history or current clinically significant cardiac disease, includingarrhythmia, aortic aneurysm, heart failure, current electrolyte abnormalities, orany other conditions that could predispose to arrhythmia in the judgement of theinvestigator