A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

Last updated: November 3, 2026
Sponsor: Eli Lilly and Company
Overall Status: Active - Recruiting

Phase

3

Condition

Diabetes Prevention

Diabetes Mellitus, Type 2

Obesity

Treatment

Placebo

Eloralintide

Clinical Study ID

NCT07282600
27741
2025
J3R-MC-YDAF
2025-523658-15-00
  • Ages > 18
  • All Genders

Study Summary

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Have type 2 diabetes

  • Are on stable treatment for type 2 diabetes for at least 90 days prior to screening

  • Have a BMI ≥ 27 kg/m2

  • Have a stable body weight (<5% body weight change) for 90 days prior to screening

Exclusion

Exclusion Criteria:

  • Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis,or abdominoplasty allowed if performed >1 year before screening)

  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 monthsprior to screening)

  • Have type 1 diabetes

  • Have taken any of the following antihyperglycemic medications within 90 days beforescreening:

  • amylin analogs

  • glucagon-like peptide-1 (GLP-1) receptor agonists

  • glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP)receptor agonists, or

  • insulin

  • Have had within 90 days prior to screening:

  • heart attack

  • stroke

  • coronary artery revascularization

  • unstable angina, or

  • hospitalization due to congestive heart failure

  • Have a history or diagnosis of New York Heart Association Functional ClassificationClass IV congestive heart failure

  • Have taken medications or alternative remedies intended for weight loss within 90days of screening

Study Design

Total Participants: 1035
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 3
Study Start date:
December 15, 2025
Estimated Completion Date:
February 29, 2028

Connect with a study center

  • Beijing Pinggu District Hospital

    Beijing, 101200
    China

    Active - Recruiting

  • Luhe Hospital

    Beijing, 100000
    China

    Active - Recruiting

  • Peking University People's Hospital

    Beijing, 100034
    China

    Active - Recruiting

  • Sichuan Provincial People's Hospital

    Chengdu, 610072
    China

    Active - Recruiting

  • The Second Affiliated Hospital Chongqing Medical University

    Chongqing, 400010
    China

    Active - Recruiting

  • Zhujiang Hospital

    Guangzhou, 510280
    China

    Active - Recruiting

  • The Second People's Hospital of Hefei

    Hefei, 230011
    China

    Active - Recruiting

  • Jinan Central Hospital

    Jinan, 250013
    China

    Active - Recruiting

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang Shi, 471023
    China

    Active - Recruiting

  • Jiangxi Provincial People's Hospital

    Nanchang, 330038
    China

    Active - Recruiting

  • Jiangsu Province Official Hospital

    Nanjing, 210008
    China

    Active - Recruiting

  • Nanjing First Hospital

    Nanjing, 210006
    China

    Active - Recruiting

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, 210011
    China

    Active - Recruiting

  • Jiading District Central Hospital

    Shanghai, 201800
    China

    Active - Recruiting

  • The Second Hospital of Tianjin Medical University

    Tianjin, 300211
    China

    Active - Recruiting

  • Zigong First People's Hospital

    Zigong, 643000
    China

    Active - Recruiting

  • MUDr. Tomas Edelsberger

    Krnov, 79401
    Czechia

    Site Not Available

  • MUDr. Miroslav Koliba s.r.o.

    Ostrava, 702 00
    Czechia

    Site Not Available

  • Diabet2 s.r.o., diabetologicka a interni ambulance

    Prague, 11000
    Czechia

    Site Not Available

  • MUDr. Jana Parkanyiova

    Prague, 110 00
    Czechia

    Site Not Available

  • Diabetespraxis Dr. Braun

    Berlin, 13187
    Germany

    Site Not Available

  • Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann

    Bünde, 32257
    Germany

    Site Not Available

  • InnoDiab Forschung Gmbh

    Essen, 45136
    Germany

    Site Not Available

  • Diabetes Zentrum Wilhelmsburg

    Hamburg, 21109
    Germany

    Site Not Available

  • Institut für Diabetesforschung GmbH Münster

    Münster, 48145
    Germany

    Site Not Available

  • Schwerpunktpraxis für Diabetes und Ernährungsmedizin Dr. med. Winfried Keuthage

    Münster, 48153
    Germany

    Site Not Available

  • RED-Institut GmbH

    Oldenburg, 23758
    Germany

    Site Not Available

  • Life Care Hospital and Research Centre

    Bangalore, 560092
    India

    Suspended

  • Hayashi Diabetes Internal Medicine Clinic

    Chigasaki, 253-0044
    Japan

    Active - Recruiting

  • Tokyo-Eki Center-building Clinic

    Chūōku, 103-0027
    Japan

    Active - Recruiting

  • Shonan Takai Clinic

    Kamakura, 247-0055
    Japan

    Active - Recruiting

  • Oishi Clinic

    Kasuya-gun, 811-2310
    Japan

    Active - Recruiting

  • OHAMA Diabetes Clinic

    Kawaguchi, 332-0015
    Japan

    Active - Recruiting

  • Higashijujo Sakai Diabetes Internal Medicine Clinic

    Kita-ku, 114-0001
    Japan

    Active - Recruiting

  • Tokuyama Clinic

    Mihama-ku,Chiba City, 261-0004
    Japan

    Active - Recruiting

  • Shinkenko clinic

    Naha, 900-0015
    Japan

    Active - Recruiting

  • Oyama East Clinic

    Oyama, 323-0022
    Japan

    Active - Recruiting

  • Shimokitazawa Tomo Clinic

    Setagaya-ku, 155-0031
    Japan

    Active - Recruiting

  • Soka Sugiura Internal Medicine Clinic

    Sōka, 340-0015
    Japan

    Active - Recruiting

  • Tsuchiura Beryl Clinic

    Tsuchiura, 300-0062
    Japan

    Active - Recruiting

  • Tsuchiura Medical & Health Care Center

    Tsuchiura, 300-0012
    Japan

    Active - Recruiting

  • Nagase Diabetes Clinic

    Ushiku, 300-1207
    Japan

    Active - Recruiting

  • Yokohama Minoru Clinic

    Yokohama, 232-0064
    Japan

    Active - Recruiting

  • Centro de Investigacion Medica de Occidente, S.C.

    Guadalajara, 44260
    Mexico

    Site Not Available

  • Instituto Jalisciense de Investigacion en Diabetes y Obesidad

    Guadalajara, 44600
    Mexico

    Site Not Available

  • Unidad de Investigación Clínica y Atención Médica HEPA S.C.

    Guadalajara, 44670
    Mexico

    Site Not Available

  • Cardiolink Clin Trials

    Monterrey, 64060
    Mexico

    Site Not Available

  • Medical Care and Research SA de CV

    Mérida, 97070
    Mexico

    Site Not Available

  • Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna

    Bialystok, 15445
    Poland

    Active - Recruiting

  • Centrum Medyczne NEUROMED

    Bydgoszcz, 85-163
    Poland

    Active - Recruiting

  • Ambulatorium Sp. z o.o.

    Elblag, 82-300
    Poland

    Active - Recruiting

  • Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET

    Krakow, 31-261
    Poland

    Active - Recruiting

  • Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

    Lodz, 90-338
    Poland

    Active - Recruiting

  • Ekamed

    Lublin, 20-718
    Poland

    Active - Recruiting

  • NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki

    Ruda Śląska, 41-709
    Poland

    Active - Recruiting

  • Samodzielny Publiczny Szpital Kliniczny nr 1 SUM

    Zabrze, 41-800
    Poland

    Active - Recruiting

  • Centro de Endocrinologia y Nutricion

    Caguas, 00725
    Puerto Rico

    Active - Recruiting

  • Dorado Medical Complex

    Dorado, 00646
    Puerto Rico

    Active - Recruiting

  • Diacrin s.r.o.

    Bratislava, 83101
    Slovakia

    Active - Recruiting

  • MediVet s.r.o.

    Malacky, 901 01
    Slovakia

    Active - Recruiting

  • FUNKYSTUFF s.r.o.

    Nové Zámky, 940 02
    Slovakia

    Active - Recruiting

  • B-Medical, s.r.o.

    Námestovo, 02901
    Slovakia

    Active - Recruiting

  • DIA-MED CENTRUM s.r.o.

    Púchov, 020 01
    Slovakia

    Active - Recruiting

  • MEDI-DIA s.r.o.

    Sabinov, 083 01
    Slovakia

    Active - Recruiting

  • Korea University Ansan Hospital

    Ansan-si, 15355
    South Korea

    Active - Recruiting

  • Hanyang University Guri Hospital

    Guri-si, 11923
    South Korea

    Active - Recruiting

  • Chosun University Hospital

    Gwangju, 61453
    South Korea

    Active - Recruiting

  • Seoul National University Bundang Hospital

    Seongnam, 13620
    South Korea

    Active - Recruiting

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722
    South Korea

    Active - Recruiting

  • Hospital Universitario de La Ribera

    Alzira, 46600
    Spain

    Site Not Available

  • Hospital Clínic de Barcelona

    Barcelona, 08036
    Spain

    Site Not Available

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035
    Spain

    Site Not Available

  • Complejo Hospitalario Ruber Juan Bravo

    Madrid, 28006
    Spain

    Site Not Available

  • H.R.U Málaga - Hospital Civil

    Málaga, 29009
    Spain

    Site Not Available

  • Hospital Universitario Virgen de la Victoria

    Málaga, 29010
    Spain

    Site Not Available

  • Centro Médico Compostela

    Santiago de Compostela, 15702
    Spain

    Site Not Available

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013
    Spain

    Site Not Available

  • Vithas Hospital Sevilla

    Seville, 41950
    Spain

    Site Not Available

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807
    Taiwan

    Active - Recruiting

  • Chang Gung Memorial Hospital at Kaohsiung

    Kaohsiung Niao Sung Dist, 83301
    Taiwan

    Active - Recruiting

  • National Taiwan University Hospital

    Taipei, 10002
    Taiwan

    Active - Recruiting

  • Taipei Veterans General Hospital

    Taipei, 11217
    Taiwan

    Active - Recruiting

  • Chang Gung Medical Foundation-Linkou Branch

    Taoyuan, 333
    Taiwan

    Active - Recruiting

  • Birmingham Clinical Research

    Birmingham, Alabama 35209
    United States

    Active - Recruiting

  • Cullman Clinical Trials

    Cullman, Alabama 35055
    United States

    Active - Recruiting

  • Tucson Clinical Research Institute

    Tucson, Arizona 85712
    United States

    Active - Recruiting

  • San Fernando Valley Health Institute

    Canoga Park, California 91304
    United States

    Active - Recruiting

  • AMCR Institute

    Escondido, California 92025
    United States

    Active - Recruiting

  • NorCal Medical Research, Inc

    Greenbrae, California 94904
    United States

    Active - Recruiting

  • Ark Clinical Research

    Long Beach, California 90815
    United States

    Active - Recruiting

  • Pacific Clinical Studies

    Los Alamitos, California 90720
    United States

    Active - Recruiting

  • Inglewood Clinical

    Los Angeles, California 90056
    United States

    Active - Recruiting

  • Care Access - Santa Clarita

    Santa Clarita, California 91321
    United States

    Active - Recruiting

  • Encompass Clinical Research

    Spring Valley, California 91978
    United States

    Active - Recruiting

  • Diablo Clinical Research, Inc.

    Walnut Creek, California 94598
    United States

    Active - Recruiting

  • Care Access - Aurora

    Aurora, Colorado 80012
    United States

    Active - Recruiting

  • New England Research Associates, LLC

    Bridgeport, Connecticut 06606
    United States

    Active - Recruiting

  • CMR of Greater New Haven, LLC

    Hamden, Connecticut 06517
    United States

    Active - Recruiting

  • Arrow Clinical Trials

    Daytona Beach, Florida 32117
    United States

    Active - Recruiting

  • Care Access - Delray Beach

    Delray Beach, Florida 33484
    United States

    Active - Recruiting

  • Fleming Island Center for Clinical Research

    Fleming Island, Florida 32003
    United States

    Active - Recruiting

  • Nature Coast Clinical Research - Inverness

    Inverness, Florida 34452
    United States

    Active - Recruiting

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida 32216
    United States

    Active - Recruiting

  • Flourish Research Acquisition, LLC dba Flourish Research - North Miami

    Miami, Florida 33138
    United States

    Active - Recruiting

  • New Horizon Research Center

    Miami, Florida 33165
    United States

    Active - Recruiting

  • Adult Medicine of Lake County, Inc.

    Mt. Dora, Florida 32757
    United States

    Active - Recruiting

  • American Research Centers of Florida

    Pembroke Pines, Florida 33027
    United States

    Active - Recruiting

  • Clinical Site Partners, LLC dba Flourish Research

    Winter Park, Florida 32789
    United States

    Active - Recruiting

  • Teak Research Consults - Dunwoody

    Dunwoody, Georgia 30338
    United States

    Active - Recruiting

  • Teak Research Consults

    Lawrenceville, Georgia 30043
    United States

    Active - Recruiting

  • The Jones Center Clinical Research

    Macon, Georgia 31210
    United States

    Active - Recruiting

  • Pacific Diabetes & Endocrine Center

    Honolulu, Hawaii 96817
    United States

    Active - Recruiting

  • NorthShore University Health System

    Skokie, Illinois 60077
    United States

    Active - Recruiting

  • DM Clinical Research - Indianapolis

    Indianapolis, Indiana 46254
    United States

    Active - Recruiting

  • Clinical Trials Management, LLC d/b/a Flourish Research

    Metairie, Louisiana 70006
    United States

    Active - Recruiting

  • IMA Clinical Research Monroe-Main

    Monroe, Louisiana 71201
    United States

    Active - Recruiting

  • Centennial Medical Group

    Columbia, Maryland 21045
    United States

    Active - Recruiting

  • Lucida Clinical Trials

    New Bedford, Massachusetts 02740
    United States

    Active - Recruiting

  • Clinical Research Professionals

    Chesterfield, Missouri 63005
    United States

    Active - Recruiting

  • Clinvest Headlands Llc

    Springfield, Missouri 65807
    United States

    Active - Recruiting

  • Hypertension & Nephrology Association

    Eatontown, New Jersey 07724
    United States

    Active - Recruiting

  • IMA Clinical Research Warren

    Warren Township, New Jersey 07059
    United States

    Active - Recruiting

  • Albuquerque Clinical Trials, Inc.

    Albuquerque, New Mexico 87102
    United States

    Active - Recruiting

  • NYC Research INC

    Long Island City, New York 11106
    United States

    Active - Recruiting

  • PharmQuest Life Sciences, LLC

    Greensboro, North Carolina 27408
    United States

    Active - Recruiting

  • West Clinical Research

    Morehead City, North Carolina 28557
    United States

    Active - Recruiting

  • Trial Management Associates - Wilmington - Floral Parkway

    Wilmington, North Carolina 28403
    United States

    Active - Recruiting

  • Lillestol Research

    Fargo, North Dakota 58104
    United States

    Active - Recruiting

  • Care Access - Lima

    Lima, Ohio 45805
    United States

    Active - Recruiting

  • Summit Headlands

    Portland, Oregon 97210
    United States

    Active - Recruiting

  • Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair

    Pittsburgh, Pennsylvania 15243
    United States

    Active - Recruiting

  • Preferred Primary Care Physicians

    Uniontown, Pennsylvania 15401
    United States

    Active - Recruiting

  • Accellacare - Mt Pleasant

    Mt. Pleasant, South Carolina 29464
    United States

    Active - Recruiting

  • IMA Clinical Research Austin

    Austin, Texas 78745
    United States

    Active - Recruiting

  • Private Practice - Dr. Osvaldo A. Brusco

    Corpus Christi, Texas 78414
    United States

    Active - Recruiting

  • Velocity Clinical Research, Dallas

    Dallas, Texas 75230
    United States

    Active - Recruiting

  • Diabetes and Thyroid Center of Ft. Worth

    Fort Worth, Texas 76132
    United States

    Active - Recruiting

  • Juno Research

    Houston, Texas 77040
    United States

    Active - Recruiting

  • Southern Endocrinology Associates

    Mesquite, Texas 75149
    United States

    Active - Recruiting

  • Research Your Health

    Plano, Texas 75093
    United States

    Active - Recruiting

  • IMA Clinical Research San Antonio

    San Antonio, Texas 78229
    United States

    Active - Recruiting

  • Ogden Clinic - Canyon View

    Ogden, Utah 84404
    United States

    Active - Recruiting

  • Diabetes & Endocrine Treatment Specialists

    Sandy City, Utah 84093
    United States

    Active - Recruiting

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