Alii Supplement Study

Last updated: January 12, 2026
Sponsor: Texas Christian University
Overall Status: Active - Recruiting

Phase

2

Condition

Affective Disorders

Mood Disorders

Treatment

Alii Supplement

Placebo

Clinical Study ID

NCT07271316
IRB#2025-383
  • Ages 18-25
  • Female

Study Summary

The goal of this clinical trial is to learn if the Alii Supplement can be used to reduce symptoms related to nutritional depletion in hormonal birth control pill users. The main questions it aims to answer are:

Does usage of the supplement increase happiness, decrease perceived vulnerability to disease, increase digestive health, decrease mood swings, and increase energy?

The investigators will compare the Alii Supplement to a placebo (a capsule that contains no drug) to see if the Alii Supplement works to reduce symptoms associated with nutritional depletion.

Participants will:

Take the placebo or Alii Supplement everyday for 28 days and visit the research office twice to fill out an online survey comprising of items examining the main outcome measures.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants must be on the hormonal birth control pill as the investigators aretesting the effectiveness of a supplement for women who take the hormonal birthcontrol pill

  • Participants must be willing to complete a follow up survey as this study will bemultiple parts

  • Participants must be willing to take a daily supplement as this study is testing howa supplement influences a variety of psychological outcomes

  • Participants must be on the hormonal birth control pill for at least six months asparticipants who have been on the pill for less than 6 months may not beexperiencing nutritional depletion yet

  • If the investigators are able to do so, the investigators will only recruitparticipants who take the one-month hormonal birth control pill rather than thethree month hormonal birth control pill, as the investigators are going to haveparticipants come in after 28 days (day 2 of pack 1 and day 2 of pack 2) andparticipants on the three-month HBC pill may be on a 21 day cycle.

  • Participants must have no food or medication allergies that will prevent theparticipants from safely taking the supplement

  • Participants must not be taking any vitamins or participant must report willingnessto abstain from taking vitamins during the study as individuals who are alreadytaking vitamins may not be experiencing nutritional depletion associated withhormonal birth control

  • If the investigators have the ability to do so, the investigators will only recruitparticipants who are not taking medications. Participants on various medications (e.g., SSRIs, ADHD medications, etc.) may report differing psychological states dueto their medications, rather than the supplement. Therefore, it would be best toexclude those individuals if possible.

Exclusion

Exclusion Criteria:

  • Participants cannot be naturally cycling as the investigators are testing asupplement for women on hormonal birth control

  • Participants cannot be unwilling to complete a follow up study because this is amulti-part study

  • Participants cannot be unwilling to take a supplement because the study centersaround taking a supplement

  • Participants cannot be on the hormonal birth control pill for less than 6 months asparticipants who have been on the pill for less than 6 months may not beexperiencing nutritional depletion yet

  • If the investigators are able to do so, participants cannot take the three monthhormonal birth control pill, as the investigators are going to have participantscome in after 28 days (day 2 of pack 1 and day 2 of pack 2) and participants on thethree-month HBC pill may be on a 21 day cycle.

  • Participants cannot have any food or medication allergies that will prevent theparticipants from safely taking the supplement

  • Participants must not be taking any vitamins or participants must report willingnessto abstain from taking vitamins during the study as individuals who are alreadytaking vitamins may not be experiencing nutritional depletion associated withhormonal birth control

  • If the investigators have the ability to do so, the investigators will only recruitparticipants who are not taking medications. Participants on various medications (e.g., SSRIs, ADHD medications, etc.) may report differing psychological states dueto their medications, rather than the supplement. Therefore, it would be best toexclude those individuals if possible.

Study Design

Total Participants: 68
Treatment Group(s): 2
Primary Treatment: Alii Supplement
Phase: 2
Study Start date:
January 12, 2026
Estimated Completion Date:
April 29, 2026

Study Description

This randomized, double-blind clinical trial will look to examine the efficacy of the Alii supplement, compared to a placebo, on reducing symptoms related to nutritional depletion in hormonal birth control pill users. This clinical trial will be conducted on 68 female university students. Participants will fill out measures of happiness, mood swings, digestive health, vulnerability to disease, and energy at time 1. Participants will then be randomly assigned to take a placebo or the Alii supplement for 28 days. Specifically, participants will take three capsules per day, with or without food. Participants will receive daily reminders to take their capsules. After taking the placebo or the supplement for 28 days, participants will again fill out the same measures of happiness, mood swings, digestive health, vulnerability to disease, and energy. Differences in these outcomes over time will be assessed to determine if taking the Alii supplement can improve these outcomes.

Connect with a study center

  • Texas Christian University

    Fort Worth 4691930, Texas 4736286 76109
    United States

    Active - Recruiting

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