Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease

Last updated: April 27, 2026
Sponsor: Regeneron Pharmaceuticals
Overall Status: Active - Recruiting

Phase

2

Condition

Diabetes Mellitus, Type 2

Treatment

ALN-ANG3

ALN-ANG3 placebo

Evinacumab placebo

Clinical Study ID

NCT07271186
ALN-ANG3-CKD-2502
  • Ages 18-80
  • All Genders

Study Summary

This study is researching experimental drugs called ALN-ANG3 and evinacumab (called "study drugs"). The study is focused on participants who have diabetic kidney disease.

The aim of the study is to see how safe and effective the study drugs are.

The study is looking at several other research questions, including:

  • What side effects may happen from taking the study drug

  • How much study drug is in the blood at different times

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  1. Medical history of type 2 diabetes and receiving medical therapy or lifestyleinterventions for glucose management

  2. Hemoglobin A1C (HbA1c) of 6.5 to 10% at screening

  3. eGFR 30 to 90 mL/min/1.73 m^2 using 2021 Chronic Kidney Disease-EpidemiologyCollaboration-Estimated Glomerular Filtration Rate using Creatinine and Cystatin C (CKD-EPI eGFRcr-cys) equation at screening

  4. Albuminuria: Urine Albumin to Creatinine Ratio (UACR) of 500 to 5000 mg/g atscreening

Exclusion

Key Exclusion Criteria:

  1. Known medical history or clinical evidence indicative of non-diabetic renal disease

  2. Renal disease that required treatment with systemic immunosuppressive therapy, or ahistory of dialysis or renal transplant

  3. Medically unstable as assessed by the investigator

  4. Hospitalization (ie, >24 hours) within 30 days of the screening visit

NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply

Study Design

Total Participants: 270
Treatment Group(s): 4
Primary Treatment: ALN-ANG3
Phase: 2
Study Start date:
January 09, 2026
Estimated Completion Date:
April 07, 2028

Connect with a study center

  • Apogee Clinical Research, LLC

    Huntsville, Alabama 35801
    United States

    Active - Recruiting

  • Applied Research Center of Arkansas

    Little Rock, Arkansas 72205
    United States

    Active - Recruiting

  • Applied Research Center of Arkansas

    Little Rock 4119403, Arkansas 4099753 72205
    United States

    Site Not Available

  • AME Clinical Research

    Huntington Beach, California 92647
    United States

    Active - Recruiting

  • Amicis Research Center

    Northridge, California 91325
    United States

    Active - Recruiting

  • FOMAT - Vista del Mar Medical Group

    Oxnard, California 93036
    United States

    Active - Recruiting

  • Central Coast Nephrology

    Salinas, California 93901
    United States

    Active - Recruiting

  • North America Research Institute

    San Dimas, California 91773
    United States

    Active - Recruiting

  • Amicis Research Center

    Santa Clarita, California 91355
    United States

    Active - Recruiting

  • Valiance Clinical Research

    Tarzana, California 91356
    United States

    Active - Recruiting

  • Amicis Research Center

    Valencia, California 91355
    United States

    Active - Recruiting

  • National Institute of Clinical Research, Inc.

    Victorville, California 92392
    United States

    Active - Recruiting

  • Amicis Research Center

    Northridge 5377985, California 5332921 91325
    United States

    Site Not Available

  • Amicis Research Center

    Santa Clarita 5393049, California 5332921 91355
    United States

    Site Not Available

  • Amicis Research Center

    Valencia 5405288, California 5332921 91355
    United States

    Site Not Available

  • D&H Doral Research Center

    Doral, Florida 33122
    United States

    Active - Recruiting

  • AGA Clinical Trials

    Hialeah, Florida 33012
    United States

    Active - Recruiting

  • Convenient Medical Center

    Hialeah, Florida 33013
    United States

    Active - Recruiting

  • Elixia Hollywood

    Hollywood, Florida 33024
    United States

    Active - Recruiting

  • D&H Pompano Research Center

    Margate, Florida 33063
    United States

    Active - Recruiting

  • D&H National Research Centers, Inc

    Miami, Florida 33155
    United States

    Active - Recruiting

  • LCC Medical Research Institute

    Miami, Florida 33126
    United States

    Active - Recruiting

  • Regenerate Primary Medical Research, LLC

    Miami, Florida 33155
    United States

    Active - Recruiting

  • Ocean Blue Medical Research Center - Internal Medicine

    Miami Springs, Florida 33166
    United States

    Active - Recruiting

  • Innovia Research Center

    Miramar, Florida 33027
    United States

    Active - Recruiting

  • Bolanos Clinical Research

    Pembroke Pines, Florida 33026
    United States

    Active - Recruiting

  • Progressive Medical Research

    Port Orange, Florida 32127
    United States

    Active - Recruiting

  • CDC Research Institute

    Port Saint Lucie, Florida 34952
    United States

    Active - Recruiting

  • D&H Tamarac Research Center

    Tamarac, Florida 33321
    United States

    Active - Recruiting

  • Metabolic Research Institute

    West Palm Beach, Florida 33401
    United States

    Active - Recruiting

  • Elixia Hollywood

    Hollywood 4158928, Florida 4155751 33024
    United States

    Site Not Available

  • Privia Medical Group of Georgia, LLC

    Savannah, Georgia 31406
    United States

    Active - Recruiting

  • Research by Design, LLC - Internal Medicine

    Chicago, Illinois 60643
    United States

    Active - Recruiting

  • Research by Design, LLC - Internal Medicine

    Chicago 4887398, Illinois 4896861 60643
    United States

    Site Not Available

  • Elixia Michigan Kidney Consultants

    Pontiac, Michigan 48341
    United States

    Active - Recruiting

  • Elixia MNA

    City of Saint Peters, Missouri 63376
    United States

    Active - Recruiting

  • Clinical Research Consultants, LLC

    Kansas City, Missouri 64111
    United States

    Active - Recruiting

  • Elixia MNA

    City of Saint Peters 4407237, Missouri 4398678 63376
    United States

    Site Not Available

  • Clinical Research Consultants, LLC

    Kansas City 4393217, Missouri 4398678 64111
    United States

    Site Not Available

  • DaVita Clinical Research

    Las Vegas, Nevada 89107
    United States

    Active - Recruiting

  • Velocity Clinical Research

    Binghamton, New York 13905
    United States

    Active - Recruiting

  • CHEAR Center LLC

    The Bronx, New York 10455
    United States

    Active - Recruiting

  • Brookview Hills Research Associates, LLC

    Winston-Salem, North Carolina 27103
    United States

    Active - Recruiting

  • Northeast Clinical Research Center

    Bethlehem, Pennsylvania 18017
    United States

    Active - Recruiting

  • Suburban Research Associates

    West Chester, Pennsylvania 19380
    United States

    Active - Recruiting

  • Northeast Clinical Research Center

    Bethlehem 5180225, Pennsylvania 6254927 18017
    United States

    Site Not Available

  • Suburban Research Associates

    West Chester 4562144, Pennsylvania 6254927 19380
    United States

    Site Not Available

  • Southeast Renal Research Institute

    Chattanooga, Tennessee 37404
    United States

    Active - Recruiting

  • Arlington Nephrology, PLLC.

    Arlington, Texas 76015
    United States

    Active - Recruiting

  • M3 Wake Research Dallas - Internal Medicine

    Dallas, Texas 75224
    United States

    Active - Recruiting

  • El Paso Kidney Specialists-Davita Clinical Research

    El Paso, Texas 79902
    United States

    Active - Recruiting

  • Clinical Trial Network, LLC

    Houston, Texas 77074
    United States

    Active - Recruiting

  • Juno Research, LLC

    Houston, Texas 77040
    United States

    Active - Recruiting

  • Gulf Coast Clinical Research

    Katy, Texas 77450
    United States

    Active - Recruiting

  • R & H Clinical Research, Inc.

    Katy, Texas 77450
    United States

    Active - Recruiting

  • Sunbeam Clinical Research

    McKinney, Texas 75069
    United States

    Active - Recruiting

  • Clinical Advancement Center

    San Antonio, Texas 78212
    United States

    Active - Recruiting

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