Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Therapy -2

Inclusion Criteria:

1. Age between 18 and 80 years;

2. Acute ischemic stroke with indications for endovascular treatment within 24 hours ofonset;

3. Anterior circulation acute ischemic stroke, with acute occlusion of the responsiblevessel located in the intracranial segment of the internal carotid artery, or the M1or M2 segment of the middle cerebral artery;

4. National Institute of Health Stroke Scale (NIHSS) score >=6;

5. Alberta Stroke Program Early CT Score (ASPECTS) >=3 points;

6. Modified Rankin Scale (mRS) score ≤4 before onset of the disease;

7. Written informed consent provided by the patients or their legal relatives.

Exclusion Criteria:

1. Evidence of intracranial hemorrhage (intracerebral hematoma (ICH), subarachnoidhemorrhage (SAH), epidural hemorrhage, acute or chronic subdural hematoma (SDH)) onthe baseline CT or MRI scan;

2. History of congenital or acquired bleeding disorders, coagulation factor deficiencydiseases, thrombocytopenic diseases, etc;

3. Anticipated difficulty in completing endovascular treatment due to vasculartortuosity;

4. Known severe allergy (more severe than skin rash) to contrast agents uncontrolled bymedications;

5. Pregnancy, breastfeeding;

6. An episode or exacerbation of congestive heart failure from any cause in the past 6months;

7. History of heart valve disease complicated by congestive heart failure within thepast 6 months;

8. Cardiac surgery with thoracotomy (eg. coronary artery bypass grafting or valvereplacement surgery) within the past 6 months;

9. Acute myocardial infarction in the past 6 months;

10. Signs or symptoms of acute myocardial infarction upon admission, includingelectrocardiographic findings;

11. Elevated serum troponin concentration upon admission (>0.1 μg/L) ;

12. Acute arrhythmia (including any tachycardia or bradycardia) with hemodynamicinstability (systolic blood pressure <100 mm Hg) upon admission;

13. Acute or chronic lung diseases requiring long-term or intermittent oxygen therapy;

14. Findings on physical examination of any of the following abnormalities: (1) Jugularvenous distension (jugular venous pulsation >4 cm above the sternal angle); (2)Resting tachycardia due to congestive heart failure (heart rate > 100 per/min); (3)Third heart sound; (4) Abnormal hepatic jugular venous reflux; (5) Pitting edema ofthe lower extremities attributable to congestive heart failure or without apparentcause; (6) Rales in both lungs; (7) Or evidence of pulmonary edema, pleuraleffusion, or pulmonary vascular redistribution on chest X-ray;

15. Severe chronic anemia (hemoglobin < 75 g/L);

16. Known recent or current serum creatinine exceeding 1.5 times the upper limit ofnormal, or estimated glomerular filtration rate (eGFR) < 60 mL/min;

17. Refractory hypertension that is difficult to control by medication (defined assystolic blood pressure > 220 mmHg, or diastolic blood pressure > 110 mmHg);

18. Serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) is greaterthan 1.5 times the upper limit of the normal value.

19. History of albumin allergy or known allergy to albumin;

20. Patients with severe mental disorders or dementia who are unable to cooperate incompleting informed consent and follow-up content;

21. The expected survival time is less than 90 days (such as comorbidity with malignanttumor or severe systemic diseases etc.);

22. Patients who have participated in other interventional clinical studies within 30days before randomization or are currently participating in other interventionalclinical studies.

23. The investigator believes that the subject has other conditions making it unsuitablefor participating in this study.