Virtual Reality Exposure Therapy for Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients

Last updated: November 20, 2025
Sponsor: National Institute of Mental Health, Czech Republic
Overall Status: Active - Recruiting

Phase

N/A

Condition

Anxiety Disorders

Obsessive-compulsive Disorder

Panic Disorders

Treatment

Cognitive flexibility training

Exposure Therapy (Virtual Reality)

Standard CBT program without VR interventions

Clinical Study ID

NCT07245134
NU23-04-00402_Study1
  • Ages 17-55
  • All Genders

Study Summary

The aim of this study is to evaluate the efficacy of virtual reality exposure therapy (VRET) as a treatment for obsessive-compulsive disorder (OCD). Participants are randomly assigned to one of the following interventions: a) exposure condition - the group with a standard CBT program enriched with exposure therapy in VR (VRET), b) control condition 1

  • the group with a standard CBT program enriched with VR cognitive training aimed at cognitive flexibility or c) control condition 2 - standard CBT program without any additional VR intervention. The treatment effect will be evaluated using pre/post assessments, as well as monitoring adherence to exposure and response prevention assignments.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of OCD (F42) using currently valid DSM-V and ICD-11

  • Fluent in Czech

Exclusion

Exclusion Criteria:

  • Any other psychiatric, neurological and serious somatic illness

  • Substance abuse

  • Psychotropic medication (e.g. benzodiazepines) except antidepressants, antipsychoticmedication and hypnotics.

  • Contradictions to using a virtual reality (e.g., epilepsy, balance problems)

  • Pregnancy

  • Cardiostimulator and mental implants

Study Design

Total Participants: 62
Treatment Group(s): 3
Primary Treatment: Cognitive flexibility training
Phase:
Study Start date:
November 15, 2022
Estimated Completion Date:
December 30, 2026

Study Description

The virtual environment of so called "OCD house" is used as a tool for the intervention in the experimental group. Immersive VR glasses HTC Vive Pro are used to visualize the virtual environment.

During exposure therapy, relevant virtual stimuli can be freely combined involving common objects and situations in the home that may trigger OCD symptoms and hoarding behavior. Target stimuli (VR elements) are divided into several sets corresponding to OCD subtypes. During the session, the therapist can modify the level of difficulty via four standardized levels according to the individual needs of the clients.

The therapeutic application enables movement and direct interaction with stimuli in the environment of the virtual house and garden, thanks to a set of handhold controllers. Direct head and body rotations and small body movements are enabled by the VR headset. The psychotherapist can follow the patient actions and control the settings of the environment (e.g.selection of relevant stimuli, level of difficulty) using the computer and screen connected to the headset, and advise the patient where necessary. The level of difficulty is gradually increased during the progress of the therapy.

Connect with a study center

  • National Institute of Mental Health

    Klecany 3073652,
    Czechia

    Active - Recruiting

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