A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006)

Last updated: May 28, 2026
Sponsor: Merck Sharp & Dohme LLC
Overall Status: Active - Recruiting

Phase

1

Condition

Diabetes Mellitus, Type 2

Treatment

MK-1403 + additive coformulation

Placebo + additive coformulation

Clinical Study ID

NCT07242469
1403-006
  • Ages 18-75
  • All Genders

Study Summary

The purpose of this study is to learn about the safety and if people tolerate a study medicine called MK-1403. The study will also measure what happens to MK-1403 in the body of a person with type 2 diabetes (T2D) over time (pharmacokinetic or PK study), and how it affects the amount of high-sensitivity C-reactive protein (hsCRP) in a person's blood.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Has a confirmed diagnosis of Type 2 diabetes mellitus (T2DM)

  • Has body mass index (BMI) between 18 and 40 kg/m^2, inclusive

Exclusion

Exclusion Criteria:

  • Has Type 1 diabetes mellitus or secondary types of diabetes

  • Has a history of congestive heart failure (New York Heart Association [NYHA] Class 3or 4)

  • Has history of myocardial infarction, uncontrolled arrhythmias, cardiacrevascularization, angina, unstable peripheral arterial disease and/or stroke

  • Has history of cancer (malignancy)

  • Has positive test(s) for hepatitis B surface antigen (HBsAg), hepatitis Cantibodies, or human immunodeficiency virus (HIV)

  • Has a history of gastrointestinal (GI) disease which might affect food and drugabsorption, or has had gastric bypass or similar surgery

Study Design

Total Participants: 52
Treatment Group(s): 2
Primary Treatment: MK-1403 + additive coformulation
Phase: 1
Study Start date:
December 22, 2025
Estimated Completion Date:
August 28, 2026

Connect with a study center

  • ProSciento Inc. ( Site 0001)

    Chula Vista, California 91911
    United States

    Active - Recruiting

  • Advanced Pharma CR, LLC ( Site 0003)

    Miami, Florida 33147
    United States

    Active - Recruiting

  • QPS-MRA, LLC ( Site 0004)

    South Miami, Florida 33143
    United States

    Active - Recruiting

  • Advanced Pharma CR, LLC ( Site 0003)

    Miami 4164138, Florida 4155751 33147
    United States

    Active - Recruiting

  • Bio-Kinetic Clinical Applications, LLC dba QPS-MO ( Site 0005)

    Springfield, Missouri 65802
    United States

    Site Not Available

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