A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight

Inclusion Criteria:

• Have a body mass index (BMI) of:

• ≥30 kilogram per square meter (kg/m2) OR

• ≥27 kg/m2 with at least one of the following weight-related conditions: highblood pressure, abnormal levels of lipid, obstructive sleep apnea, heartdisease

• Have at least one unsuccessful attempt to lose weight by dieting

Exclusion Criteria:

• Have a self-reported change in body weight >5 kg (11 pounds) within 90 days beforescreening

• Have a prior or planned surgical treatment for obesity

• Have type 1 diabetes or type 2 diabetes

• Have a family or personal history of medullary thyroid carcinoma (MTC) or multipleendocrine neoplasia syndrome type 2 (MEN-2)

• Have had within the past 90 days before screening

• acute myocardial infarction

• cerebrovascular accident (stroke)

• hospitalization for unstable angina, or

• hospitalization due to congestive heart failure

• Have New York Heart Association Functional Classification Class IV congestive heartfailure

• Have a history of chronic or acute pancreatitis

• Have taken weight loss drugs, including over-the counter medications within 90 daysprior to screening