Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry

Last updated: November 14, 2025
Sponsor: Universidad Austral de Chile
Overall Status: Active - Not Recruiting

Phase

4

Condition

Acute And Chronic Dental Pain

Acute Pain

Oral Facial Pain

Treatment

Articaine 4% with epinephrine 1:100,000

lidocaine + epinephrine 1:100,000

Clinical Study ID

NCT07231614
ArtiVsLido
  • Ages 18-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Context: Lidocaine and articaine are two of the most commonly used local anesthetics in dentistry. Lidocaine has often been the anesthetic of choice in clinical practice, but in clinical experience, articaine has proven to be more effective in controlling pain during dental procedures. (Camps-Font, O. et al. 2020).

There are still unanswered questions, such as which of the two local anesthetics is more effective in reducing pain? This could lead us to discuss which one to choose to reduce costs in the dental office.

Objective: The objective of this project is to determine and compare the effectiveness of lidocaine and articaine in clinical contexts such as tooth extraction with infiltrative techniques, seeking to provide answers that will optimize the choice of anesthetic based on the patient and the procedure, thus improving pain management and reducing costs in the dental office.

Design: Randomized double-blind experimental study, parallel groups. The control group received 2% lidocaine, and the experimental group received 4% articaine. The study will be conducted in accordance with the guidelines of the Consolidated Standards of Reporting Trials (CONSORT 2010). The probabilistic sampling technique is through simple randomization. The 100 patients who meet the inclusion criteria will be randomly assigned to the control and experimental groups in a 1:1 ratio.

Expected results: articaine shows a lower percentage of extractions with anesthetic reinforcement and, therefore, a lower average number of additional tubes.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with clinical indications for simple extraction of upper and lower teethusing infiltrative anesthetic techniques.

  • Patients without systemic diseases (ASA I)

  • Patients with controlled systemic disease (ASA II)

  • Patients with no history of hypersensitivity to anesthetics or their components (epinephrine)

  • Patients with stable periodontal condition, without active infection that couldaffect the diffusion of the anesthetic.

  • Patients with the ability to understand the procedure and provide informed consent.

Exclusion

Exclusion Criteria:

  • Patients with uncontrolled systemic diseases ASA III and pregnant patients.

  • Patients requiring trunk techniques (Gow gates, Spix, Carrea)

  • Patients taking medication that affects the anesthetic response (tricyclicantidepressants, anticoagulants)

  • Patients with a history of neurological or psychiatric disorders that may influencethe perception of pain or anxiety.

  • Patients with anatomical abnormalities in the orofacial region that interfere withthe administration or action of anesthesia.

  • Patients with a history of recent substance abuse.

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: Articaine 4% with epinephrine 1:100,000
Phase: 4
Study Start date:
December 20, 2025
Estimated Completion Date:
January 25, 2026

Connect with a study center

  • CESFAM Dr. Jorge Sabat

    Valdivia 3868707, Los Ríos Region 6693563 5090000
    Chile

    Site Not Available

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