A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Inclusion Criteria:

The main inclusion criteria include but are not limited to the following:

• Has a histologically confirmed diagnosis of unresectable, advanced renal cell cancer (RCC) with clear cell component (with or without sarcomatoid features) i.e., StageIV renal cell cancer per American Joint Committee on Cancer (AJCC) (8th Edition)

• Has measurable disease per Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1)

• Has disease recurrence during adjuvant anti-programmed cell death 1/programmed celldeath ligand 1 (PD-1/L1) therapy or recurrence ≤24 months following the last dose ofadjuvant anti-PD-1/L1 therapy

• Has received no other prior systemic therapy for their RCC except for their adjuvantanti-PD-1/L1 therapy

Exclusion Criteria:

The main exclusion criteria include but are not limited to the following:

• Has clinically significant cardiovascular disease within 12 months from first doseof study intervention, including New York Heart Association Class III or IVcongestive heart failure, unstable angina, new-onset angina, pulmonary embolism,myocardial infarction, cerebral vascular accident, or cardiac arrhythmia associatedwith hemodynamic instability

• Had deep vein thrombosis within 3 months before randomization unless stable,asymptomatic, and treated with therapeutic anticoagulation for at least 4 weeksbefore randomization

• Has a left ventricular ejection fraction ≤50% or below the institutional (or locallaboratory) normal range as determined by multigated acquisition or echocardiogram

• Has had major surgery within 8 weeks before randomization or has not adequatelyrecovered from major surgery or has ongoing surgical complications

• Has current pneumonitis/interstitial lung disease

• Has symptomatic pleural effusion (for example cough, dyspnea, pleuritic chest pain),ascites, or pericardial fluid requiring drainage within 4 weeks prior torandomization

• Has a gastrointestinal disorder including those associated with a high risk ofperforation or fistula formation

• Has a serious active nonhealing wound/ulcer/bone fracture

• Has a requirement for hemodialysis or peritoneal dialysis

• Has history of human immunodeficiency virus infection

• Has hepatitis B or hepatitis C virus

• Received a live or live-attenuated vaccine within 30 days before the first dose ofstudy intervention