Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide

Key Inclusion Criteria:

• Informed consent obtained before any study-related activities. Study-relatedactivities are any procedures that are carried out as part of the study, includingactivities to determine suitability for the study.

• Female or male (sex at birth).

• Age 18 years or above at the time of signing the informed consent.

• History of at least one self-reported unsuccessful dietary effort to lose bodyweight.(a*)

• Body mass index (BMI) >= 27.0 kilogram per square meter (kg/m^2).(a*)

• Diagnosed with type 2 diabetes >= 180 days before screening.

• Treatment with either lifestyle intervention(a*), or:

• Stable treatment (same drug(s), dose and dosing frequency) for at least 90 daysbefore screening with 1-3 marketed oral antidiabetic drugs (metformin, α-glucosidase inhibitors (AGI), glinides, sodium-glucose cotransporter 2inhibitor (SGLT2i), thiazolidinediones, Dipeptidyl peptidase-4 inhibitor (DPP-4i) or sulphonylureas (SU) as a single agent or in combination accordingto local practice.(a*)

• For up to 30% of participants the following concomitant medication is allowed:

• Treatment for any indication with a stable dose of glucagon-like peptide-1 (GLP-1) containing medication, stable for at least 1 year before screening (a*) and/or

• Treatment with basal insulin minimum (0.25 units per kilogram per day (U/kg/day) or 20 units per day [U/day]) stable for at least 90 days beforescreening.(a*)

Key Exclusion Criteria:

• Treatment, or intention to initiate treatment, with any medication prescribed forthe indication of weight management within 180 days before screening.(a*)

• Treatment with glucagon-like peptide-1 (GLP-1) receptor agonist (RA) or GLP-1containing medication within 180 days before screening, apart from those randomizedaccording to inclusion criteria 7bi.(a*)

• Previous dosing of marketed or non-marketed amylin-based compounds.(a*) (a*) - Asdeclared by the participant, reported in the medical records or at theinvestigator's discretion.