Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide

Last updated: April 6, 2026
Sponsor: Novo Nordisk A/S
Overall Status: Active - Not Recruiting

Phase

3

Condition

Obesity

Diabetes Prevention

Hypertriglyceridemia

Treatment

Placebo

Cagrilintide

Clinical Study ID

NCT07220642
NN9833-8242
2024-519530-24
U1111-1314-8906
  • Ages > 18
  • All Genders

Study Summary

This study will look at how much cagrilintide helps people with overweight or obesity lower their body weight. Cagrilintide is a new investigational medicine. Doctors may not yet prescribe cagrilintide. Participants will either get cagrilintide or placebo. Which treatment participants get is decided by chance. Participants are two times more likely to get cagrilintide than placebo. Like all medicines, the study medicine may have side effects. Possible side effects will be followed carefully during the study. For each participant, the study will last for about 1 year and 6 months.

Eligibility Criteria

Inclusion

Inclusion criteria:

  • Informed consent obtained before any study-related activities. Study-relatedactivities are any procedures that are carried out as part of the study, includingactivities to determine suitability for the study

  • Female or male (sex at birth)

  • Age 18 years or above at the time of signing the informed consent

  • History of at least one self-reported unsuccessful dietary effort to lose bodyweight (a*)

  • Body mass index (BMI) greater than or equal to >= 30.0 kilogram per square meter (kg/m^2), or BMI greater than or equal to >= 27.0 kg/m^2 with the presence of atleast one weight related comorbidity including, but not limited to, hypertension,dyslipidaemia, obstructive sleep apnoea or cardiovascular disease (a*)

Exclusion

Exclusion criteria:

  • History of type 1 or type 2 diabetes (a*)

  • Treatment, or intention to initiate treatment, with any medication prescribed forthe indication of weight management within 180 days before screening (a*)

  • Previous dosing of marketed or non-marketed amylin-based compounds (a*) (a*) - Asdeclared by the participant, reported in the medical records or at theinvestigator's discretion.

Study Design

Total Participants: 300
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 3
Study Start date:
November 05, 2025
Estimated Completion Date:
June 29, 2027

Connect with a study center

  • CIPREC Pueyrredon

    Buenos Aires, C1119ACN
    Argentina

    Site Not Available

  • CIPREC Pueyrredon

    Buenos Aires 3435910, C1119ACN
    Argentina

    Site Not Available

  • CEDIC Centro de Investigación Clínica

    CABA, C1060ABA
    Argentina

    Site Not Available

  • Sydney Cardiometabolic Centre

    Liverpool, New South Wales 2170
    Australia

    Site Not Available

  • Hunter Diabetes Centre

    Merewether, New South Wales 2291
    Australia

    Site Not Available

  • Sydney Cardiometabolic Centre

    Liverpool 2159851, New South Wales 2155400 2170
    Australia

    Site Not Available

  • Hunter Diabetes Centre

    Merewether 8348074, New South Wales 2155400 2291
    Australia

    Site Not Available

  • G.A. Research Associates Ltd.

    Moncton, New Brunswick E1G 1A7
    Canada

    Site Not Available

  • G.A. Research Associates Ltd.

    Moncton 6076211, New Brunswick 6087430 E1G 1A7
    Canada

    Site Not Available

  • Nova Scotia Hlth Halifax

    Halifax, Nova Scotia B3H 1V7
    Canada

    Site Not Available

  • Nova Scotia Hlth Halifax

    Halifax 6324729, Nova Scotia 6091530 B3H 1V7
    Canada

    Site Not Available

  • Hamilton Medical Rsrch Grp

    Hamilton, Ontario L8L 5G4
    Canada

    Site Not Available

  • Wharton Medical Clinic Clinical Trials (Hamilton)

    Hamilton, Ontario L8L 5G8
    Canada

    Site Not Available

  • Milestone Research

    London, Ontario N5W 6A2
    Canada

    Site Not Available

  • Centricity Research Oshawa

    Oshawa, Ontario L1J 2K9
    Canada

    Site Not Available

  • Centricity Research Toronto

    Toronto, Ontario M4G 3E8
    Canada

    Site Not Available

  • Hamilton Medical Rsrch Grp

    Hamilton 5969782, Ontario 6093943 L8L 5G4
    Canada

    Site Not Available

  • Wharton Med Clin Trials

    Hamilton 5969782, Ontario 6093943 L8L 5G8
    Canada

    Site Not Available

  • Milestone Research

    London 6058560, Ontario 6093943 N5W 6A2
    Canada

    Site Not Available

  • Centricity Research Oshawa

    Oshawa 6094578, Ontario 6093943 L1J 2K9
    Canada

    Site Not Available

  • Centricity Research Toronto

    Toronto 6167865, Ontario 6093943 M4G 3E8
    Canada

    Site Not Available

  • Centricity Research Mirabel

    Mirabel, Quebec J7J 2K8
    Canada

    Site Not Available

  • Centricity Research Mirabel

    Mirabel 6075061, Quebec 6115047 J7J 2K8
    Canada

    Site Not Available

  • Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec

    Saint-Herblain, 44800
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec

    Saint-Herblain 2979590, 44800
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec-1

    Saint-Herblain 2979590, 44800
    France

    Active - Recruiting

  • Centre de Recherche Clinique Portes Du Sud

    Vénissieux, 69200
    France

    Site Not Available

  • Centre de Recherche Clinique Portes Du Sud

    Vénissieux 2970072, 69200
    France

    Site Not Available

  • InnoDiab Forschung GmbH

    Essen, 45136
    Germany

    Site Not Available

  • InnoDiab Forschung GmbH

    Essen 2928810, 45136
    Germany

    Site Not Available

  • Wendisch - Dahl Hamburg - DZHW

    Hamburg, 22607
    Germany

    Site Not Available

  • Wendisch - Dahl Hamburg - DZHW

    Hamburg 2911298, 22607
    Germany

    Site Not Available

  • Wendisch/Dahl Hamburg (DZHW)

    Hamburg 2911298, 22607
    Germany

    Active - Recruiting

  • RED-Institut für medizinische Forschung und Fortbildung GmbH

    Oldenburg in Holstein, 23758
    Germany

    Site Not Available

  • RED-Institut für medizinische Forschung und Fortbildung GmbH

    Oldenburg in Holstein 2857451, 23758
    Germany

    Site Not Available

  • Fondazione Policlinico Universitario Agostino Gemelli IRCS

    Rome, RM 00168
    Italy

    Site Not Available

  • Fondazione Policlinico Universitario Agostino Gemelli IRCS

    Rome 3169070, RM 00168
    Italy

    Site Not Available

  • AOUP Giaccone Palermo

    Palermo, Sicily 90127
    Italy

    Site Not Available

  • AOUP Giaccone Palermo

    Palermo 2523920, Sicily 2523119 90127
    Italy

    Site Not Available

  • A.O.U. Bologna_ Policlinico S.Orsola Malpighi

    Bologna, 40138
    Italy

    Site Not Available

  • A.O.U. Bologna_ Policlinico S.Orsola Malpighi

    Bologna 3181928, 40138
    Italy

    Site Not Available

  • IRCCS Ospedale San Raffaele Milano

    Milan, 20132
    Italy

    Site Not Available

  • IRCCS Ospedale San Raffaele Milano

    Milan 6951411, 20132
    Italy

    Site Not Available

  • Haukeland Universitetssykehus

    Bergen, 5021
    Norway

    Site Not Available

  • Haukeland Universitetssykehus

    Bergen 3161732, 5021
    Norway

    Site Not Available

  • Drammen sykehus - Vestre Viken HF

    Drammen, 3004
    Norway

    Site Not Available

  • Drammen sykehus - Vestre Viken HF

    Drammen 3159016, 3004
    Norway

    Site Not Available

  • St. Olavs Hospital HF_Endokrinologisk avdeling

    Trondheim, NO-7030
    Norway

    Site Not Available

  • St. Olavs Hospital HF

    Trondheim 3133880, NO-7030
    Norway

    Site Not Available

  • Osteo-Medic s.c. A. Racewicz, J. Supronik

    Bialystok, 15-351
    Poland

    Site Not Available

  • Osteo-Medic s.c. A. Racewicz, J. Supronik

    Bialystok 776069, 15-351
    Poland

    Site Not Available

  • Care Clinic Sp. z o. o.

    Katowice, 40-568
    Poland

    Site Not Available

  • Care Clinic Sp. z o. o.

    Katowice 3096472, 40-568
    Poland

    Site Not Available

  • Terpa Sp. z o.o. Sp. k.

    Lublin, 20-333
    Poland

    Site Not Available

  • Terpa Sp. z o.o. Sp. k.

    Lublin 765876, 20-333
    Poland

    Site Not Available

  • NBR Polska Tomasz Klodawski

    Warsaw, 00-710
    Poland

    Site Not Available

  • NBR Polska Tomasz Klodawski

    Warsaw 756135, 00-710
    Poland

    Site Not Available

  • Oak Tree Surgery

    Liskeard, Cornwall PL14 3XA
    United Kingdom

    Site Not Available

  • Oak Tree Surgery

    Liskeard 2644409, Cornwall PL14 3XA
    United Kingdom

    Site Not Available

  • North Coast Medical Ltd

    Newquay, Cornwall TR7 1RU
    United Kingdom

    Site Not Available

  • North Coast Medical Ltd

    Newquay 2641589, Cornwall TR7 1RU
    United Kingdom

    Site Not Available

  • Brunel Medical Practice

    Torquay, Devon TQ1 4QX
    United Kingdom

    Site Not Available

  • Brunel Medical Practice

    Torquay 2635650, Devon TQ1 4QX
    United Kingdom

    Site Not Available

  • Diablo Clinical Research, Inc.

    Walnut Creek, California 94598
    United States

    Site Not Available

  • Diablo Clinical Research, Inc.

    Walnut Creek 5406990, California 5332921 94598
    United States

    Site Not Available

  • Univ of Colorado at Denver

    Aurora, Colorado 80045
    United States

    Site Not Available

  • Univ of Colorado at Denver

    Aurora 5412347, Colorado 5417618 80045
    United States

    Site Not Available

  • Florida Inst For Clin Res LLC

    Orlando, Florida 32825
    United States

    Site Not Available

  • Oviedo Medical Research, LLC

    Oviedo, Florida 32765
    United States

    Site Not Available

  • Florida Inst For Clin Res LLC

    Orlando 4167147, Florida 4155751 32825
    United States

    Site Not Available

  • Oviedo Medical Research, LLC

    Oviedo 4167348, Florida 4155751 32765
    United States

    Site Not Available

  • Walgreens - Store 11760

    Oak Park, Illinois 60302
    United States

    Site Not Available

  • Walgreens - Store 11760

    Oak Park 4904381, Illinois 4896861 60302
    United States

    Site Not Available

  • Midwest Inst For Clin Res

    Indianapolis, Indiana 46260
    United States

    Site Not Available

  • Midwest Inst For Clin Res

    Indianapolis 4259418, Indiana 4921868 46260
    United States

    Site Not Available

  • StudyMetrix Research LLC

    City of Saint Peters, Missouri 63303
    United States

    Site Not Available

  • StudyMetrix Research LLC

    City of Saint Peters 4407237, Missouri 4398678 63303
    United States

    Site Not Available

  • PharmQuest Life Sciences LLC

    Greensboro, North Carolina 27408
    United States

    Site Not Available

  • PharmQuest Life Sciences LLC

    Greensboro 4469146, North Carolina 4482348 27408
    United States

    Site Not Available

  • Selma Medical Associates

    Winchester, Virginia 22601-3834
    United States

    Site Not Available

  • Selma Medical Associates

    Winchester 4794120, Virginia 6254928 22601-3834
    United States

    Site Not Available

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