A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder

Inclusion Criteria:

• Participant must be a minimum of 20 years of age for the investigative sites inJapan.

• Are seeking treatment and are motivated to stop or cut down on drinking.

• Are reliable and willing to make themselves available for the duration of the studyand attend required study visits, and are willing and able to follow studyprocedures as required, such as

• self-inject study intervention

• store and use the provided blinded study intervention, as directed

• maintain electronic and paper study diaries, as applicable, and

• complete the required questionnaires.

Exclusion Criteria:

• Have evidence of current or within the past 180 days prior to screening (V1),history of any substance use disorder(s) of any severity with a pattern ofpersistent illicit or nonprescribed substance use as indicated by clinicalinterview, except alcohol, nicotine, or caffeine.

• Have answered "yes" to either Question 4 or Question 5 on the "Suicidal Ideation"portion of the Columbia-Suicide Severity Rating Scale (C-SSRS) and the ideationoccurred within the past 6 months, or have answered "yes" to any of thesuicide-related behaviors on the "Suicidal Behavior" portion of the C-SSRS and thebehavior occurred within the past 6 months

• Have a history of advanced liver disease (including advanced liver fibrosis orcirrhosis), or alcohol-associated hepatitis based on either prior liver histology orimaging studies, such as transient elastography, ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI), or Enhanced Liver Fibrosis score.

• Have participated in a clinical study and have received active treatment, or unknownif they received active treatment, within 90 days or 5 half-lives (whichever islonger) before screening (V1).