A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

Inclusion Criteria:

• Participant has provided informed consent before initiation of any study-specificactivities/procedures.

• Age ≥ 18 years (or ≥ legal age within the country if it is older than 18 years) atthe time of signing the informed consent.

• Participant must have histological, pathological, and/or cytological confirmation ofadenocarcinoma of the prostate. Mixed histologies (eg, adenocarcinoma withneuroendocrine component) are not permitted.

• Metastatic castration-resistant prostate cancer (mCRPC) with ≥ 1 metastatic lesionthat is present on baseline computed tomography (CT), magnetic resonance imaging (MRI), or bone scan imaging obtained within 28 days before enrollment.

• Evidence of progressive disease (PD), defined as 1 or more PCWG3-modified RECIST 1.1criteria:

• Serum PSA progression is defined as 2 consecutive increases in PSA over aprevious reference value measured at least 1 week prior. The minimum startvalue is 2.0 ng/mL.

• Soft-tissue progression defined as an increase ≥ 20% in the sum of the diameter (SOD) (short axis for nodal lesions and long axis for non-nodal lesions) of alltarget lesions based on the smallest SOD since treatment started or theappearance of 1 or more new lesions or unequivocal progression of existingnon-target lesions.

• Progression of bone disease defined by the appearance of at least 2 new bonelesions(s) by bone scan (as per the 2+2 PCWG3-modified RECIST 1.1 criteria).

• Participants must have had prior orchiectomy and/or ongoing androgen-deprivationtherapy (ADT) and a castrate level of serum testosterone (< 50 ng/dL or < 1.7nmol/L).

• Prior disease progression on 1, and only 1, androgen receptor pathway inhibitor (ARPI) (either enzalutamide, apalutamide, or darolutamide) is required.

• Participants intended to receive cabazitaxel must have previously received ≤ 6cycles of docetaxel in the metastatic hormone-sensitive prostate cancer (mHSPC)setting.

• Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1.

• Adequate organ function.

Exclusion Criteria:

Disease Related:

• Participants with a history of central nervous system (CNS) metastases.

• Unresolved toxicities from prior antitumor therapy not having resolved to CTCAEversion 5.0 grade 1 or baseline, with the exception of alopecia or toxicities thatare stable and well-controlled AND there is an agreement to allow inclusion by boththe investigator and the sponsor.

Prior/Concomitant Therapy:

• Prior six transmembrane epithelial antigen of the prostate 1 (STEAP1)-targetedtherapy.

• Prior disease progression on or intolerance to abiraterone.

• Prior treatment with any chemotherapy regimen in the mCRPC setting and/or > 6 cyclesof docetaxel treatment in the mHSPC setting.

• Any anticancer therapy, immunotherapy, or investigational agent within 4 weeksbefore first dose of study treatment with the following exceptions:

• Androgen receptor pathway inhibitors (ARPIs; enzalutamide, darolutamide,apalutamide): minimum washout of 2 weeks prior to the first dose of studytreatment.

• Androgen suppression therapy (eg, luteinizing hormone-releasinghormone/gonadotrophin releasing hormone [LHRH/GnRH] analogue [agonist/antagonist]) is permitted.

• Prior radioligand therapy (RLT) within 8 weeks of first dose of study treatment.

• Prior radionuclide therapy (radium-223) within 2 months of first dose of studytreatment.

• Prior palliative radiotherapy within 2 weeks before first dose of study treatment.Participants must have recovered from all radiation-related toxicities.

• Concurrent cytotoxic chemotherapy, ARPI, immunotherapy, RLT, poly adenosinediphosphate ribose polymerase (PARP) inhibitor, biological therapy, investigationaltherapy.

• Treatment with live and live-attenuated vaccines within 4 weeks before the firstdose of study treatment.

• Prior CD3-directed therapy.