Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)

Last updated: April 23, 2026
Sponsor: Vertex Pharmaceuticals Incorporated
Overall Status: Active - Recruiting

Phase

2/3

Condition

Idiopathic Membranous Nephropathy

Treatment

Povetacicept

Tacrolimus

Clinical Study ID

NCT07204275
VX24-AIS-D10
2025-521661-27-00
  • Ages 18-75
  • All Genders

Study Summary

The purpose of this study is to evaluate the efficacy, safety, and tolerability of povetacicept in participants with primary membranous nephropathy (pMN).

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

• Diagnosed with pMN with confirmatory historical biopsy. If no historical biopsy was performed that confirmed pMN, a biopsy can be performed during Screening to confirm eligibility

Exclusion

Key Exclusion Criteria:

• Hypersensitivity to investigational medicinal product or to any of its excipients

Other protocol defined Inclusion/Exclusion criteria will apply

Study Design

Total Participants: 176
Treatment Group(s): 2
Primary Treatment: Povetacicept
Phase: 2/3
Study Start date:
September 30, 2025
Estimated Completion Date:
December 29, 2028

Connect with a study center

  • St George Private Hospital

    Kogarah,
    Australia

    Active - Recruiting

  • St George Private Hospital

    Kogarah 2161185,
    Australia

    Site Not Available

  • University of Newcastle - John Hunter Hospital (JHH)

    New Lambton Heights,
    Australia

    Active - Recruiting

  • University of Newcastle - John Hunter Hospital (JHH)

    New Lambton Heights 10103866,
    Australia

    Site Not Available

  • Santa Casa de Misericordia

    Porto Alegre,
    Brazil

    Active - Recruiting

  • Fundação Bahiana de Infectologia

    Salvador,
    Brazil

    Active - Recruiting

  • Hospital das Clinicas da Faculdade de Medicina da USP - HC- FMUSP

    São Paulo,
    Brazil

    Active - Recruiting

  • The First Affiliated Hospital of Baotou Medical College

    Baotou,
    China

    Active - Recruiting

  • Beijing Tsinghua Changgung Hospital

    Beijing,
    China

    Active - Recruiting

  • Peking University First Hospital

    Beijing,
    China

    Active - Recruiting

  • Beijing Tsinghua Changgung Hospital

    Beijing 1816670,
    China

    Site Not Available

  • Peking University First Hospital

    Beijing 1816670,
    China

    Active - Recruiting

  • The First Affiliated Hospital of Bengbu Medical University

    Bengbu,
    China

    Active - Recruiting

  • The First Affiliated Hospital of Bengbu Medical University

    Bengbu 1816440,
    China

    Site Not Available

  • The Second Norman Bethune Hospital of Jilin University

    Changchun,
    China

    Active - Recruiting

  • Xiangya Hospital of Central South University

    Changsha,
    China

    Active - Recruiting

  • Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People's Hospital

    Chengdu,
    China

    Active - Recruiting

  • Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People's Hospital

    Chengdu 1815286,
    China

    Site Not Available

  • Dalian Municipal Central Hospital

    Dalian,
    China

    Active - Recruiting

  • Dalian Municipal Central Hospital

    Dalian 1814087,
    China

    Site Not Available

  • Dongguan People's Hospital

    Dongguan,
    China

    Active - Recruiting

  • Dongguan People's Hospital

    Dongguan 1812545,
    China

    Site Not Available

  • Fuyang People's Hospital

    Fuyang,
    China

    Active - Recruiting

  • Fuyang People's Hospital

    Fuyang 1810845,
    China

    Site Not Available

  • Guangdong Provincial People's Hospital

    Guangzhou,
    China

    Active - Recruiting

  • The First Affiliated Hospital,Sun Yat-sen University

    Guangzhou,
    China

    Active - Recruiting

  • Guangdong Provincial People's Hospital

    Guangzhou 1809858,
    China

    Active - Recruiting

  • The First Affiliated Hospital,Sun Yat-sen University

    Guangzhou 1809858,
    China

    Site Not Available

  • The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University

    Huai'an,
    China

    Active - Recruiting

  • The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University

    Huai'an 1797873,
    China

    Site Not Available

  • The Second Qilu Hospital of Shandong University

    Jinan,
    China

    Active - Recruiting

  • The Second Qilu Hospital of Shandong University

    Jinan 1805753,
    China

    Site Not Available

  • Liu Zhou Works Hospital

    Liuchow,
    China

    Active - Recruiting

  • Liu Zhou Works Hospital

    Liuchow 1803300,
    China

    Site Not Available

  • The First Affiliated Hospital of Nanchang University

    Nanchang,
    China

    Active - Recruiting

  • The First Affiliated Hospital of Nanchang University

    Nanchang 1800163,
    China

    Site Not Available

  • The People's Hospital of Guangxi Zhuang Autonomous Region

    Nanning,
    China

    Active - Recruiting

  • The People's Hospital of Guangxi Zhuang Autonomous Region

    Nanning 1799869,
    China

    Site Not Available

  • Nanyang Central Hospital

    Nanyang,
    China

    Active - Recruiting

  • Nanyang Central Hospital

    Nanyang 1799629,
    China

    Site Not Available

  • The First Affiliated Hospital of Ningbo University

    Ningbo,
    China

    Active - Recruiting

  • The First Affiliated Hospital of Ningbo University

    Ningbo 1799397,
    China

    Site Not Available

  • Renji Hospital Shanghai Jiaotong University School of Medicine

    Shanghai,
    China

    Active - Recruiting

  • Shanghai General Hospital

    Shanghai,
    China

    Active - Recruiting

  • Shanghai General Hospital

    Shanghai 1796236,
    China

    Site Not Available

  • The First Hospital of Hebei Medical University

    Shijiazhuang,
    China

    Active - Recruiting

  • The Second Hospital of Hebei Medical University

    Shijiazhuang,
    China

    Active - Recruiting

  • The First Hospital of Hebei Medical University

    Shijiazhuang 1795270,
    China

    Site Not Available

  • The Second Hospital of Hebei Medical University

    Shijiazhuang 1795270,
    China

    Active - Recruiting

  • Tai'an City Central Hosptial

    Tai’an,
    China

    Active - Recruiting

  • Tai'an City Central Hosptial

    Tai’an 1793724,
    China

    Site Not Available

  • Weifang People's Hospital

    Weifang,
    China

    Active - Recruiting

  • Weifang People's Hospital

    Weifang 1791681,
    China

    Site Not Available

  • Wuxi People's Hospital

    Wuxi,
    China

    Active - Recruiting

  • Wuxi People's Hospital

    Wuxi 1790923,
    China

    Site Not Available

  • The First Affiliated Hospital of Xi 'an Jiaotong University

    Xi'an,
    China

    Active - Recruiting

  • The First Affiliated Hospital of Xi 'an Jiaotong University

    Xi'an 1790630,
    China

    Site Not Available

  • The First Affiliated Hospital of Xiamen University

    Xiamen,
    China

    Active - Recruiting

  • The First Affiliated Hospital of Xiamen University

    Xiamen 1790645,
    China

    Site Not Available

  • Yantai YuHuangDing Hospital

    Yantai,
    China

    Active - Recruiting

  • Yantai YuHuangDing Hospital

    Yantai 1787093,
    China

    Site Not Available

  • Yichang Central People Hospital

    Yichang,
    China

    Active - Recruiting

  • Yichang Central People Hospital

    Yichang 1786764,
    China

    Site Not Available

  • Vseobecna fakultni nemocnice v Praze - Klinika nefrologie

    Prague,
    Czechia

    Active - Recruiting

  • Charite - Universitaetsmedizin Berlin Campus Benjamin Frankl

    Allemagne,
    Germany

    Active - Recruiting

  • Klinikum St. Georg gGmbH - Nephrology

    Leipzig,
    Germany

    Active - Recruiting

  • Universitaetsklinikum Leipzig - Medizinische Klinik und Poliklinik III - Klinik und Poliklinik fuer Endokrinologie, Nephrologie

    Leipzig,
    Germany

    Active - Recruiting

  • Klinikum St. Georg gGmbH - Nephrology

    Leipzig 2879139,
    Germany

    Site Not Available

  • Universitaetsklinikum Wuerzburg - Innere Medizin, Nephrologie

    Würzburg,
    Germany

    Active - Recruiting

  • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

    Szeged,
    Hungary

    Active - Recruiting

  • Beaumont Hospital

    Dublin,
    Ireland

    Active - Recruiting

  • Azienda Ospedaliera Universitaria Federico II

    Naples,
    Italy

    Active - Recruiting

  • Fondazione Salvatore Maugeri - Nefrologia e Dialisi

    Pavia,
    Italy

    Active - Recruiting

  • Kanazawa University Hospital

    Kanazawa,
    Japan

    Active - Recruiting

  • Kasugai Municipal Hospital

    Kasugai,
    Japan

    Active - Recruiting

  • The University of Osaka Hospital

    Suita,
    Japan

    Active - Recruiting

  • Fujita Health University

    Toyoake-Shi,
    Japan

    Active - Recruiting

  • Hallym University Sacred Heart Hospital

    Anyang-si,
    South Korea

    Active - Recruiting

  • Hallym University Sacred Heart Hospital

    Anyang-si 1846898,
    South Korea

    Site Not Available

  • Korea University Anam Hospital - Nephrology

    Seoul,
    South Korea

    Active - Recruiting

  • Kyung Hee University Hospital at Gangdong - Nephrology

    Seoul,
    South Korea

    Active - Recruiting

  • Samsung Medical Center - Nephrology

    Seoul,
    South Korea

    Active - Recruiting

  • Severance Hospital, Yonsei University Health System - Nephrology

    Seoul,
    South Korea

    Active - Recruiting

  • Korea University Anam Hospital - Nephrology

    Seoul 1835848,
    South Korea

    Active - Recruiting

  • Kyung Hee University Hospital at Gangdong - Nephrology

    Seoul 1835848,
    South Korea

    Active - Recruiting

  • Samsung Medical Center - Nephrology

    Seoul 1835848,
    South Korea

    Site Not Available

  • Severance Hospital, Yonsei University Health System - Nephrology

    Seoul 1835848,
    South Korea

    Active - Recruiting

  • Yongin Severance Hospital - Nephrology

    Yongin-si,
    South Korea

    Active - Recruiting

  • Hospital Universitari Vall D Hebron

    Barcelona,
    Spain

    Active - Recruiting

  • Hospital Universitari Vall D Hebron

    Barcelona 3128760,
    Spain

    Site Not Available

  • Hospital Universitario Reina Sofia

    Córdoba,
    Spain

    Active - Recruiting

  • Hospital Universitario Reina Sofia

    Córdoba 2519240,
    Spain

    Site Not Available

  • Hospital Ribera Polusa

    Lugo,
    Spain

    Active - Recruiting

  • Clinica Universidad de Navarra - Nefrología

    Pamplona,
    Spain

    Active - Recruiting

  • Clinica Universidad de Navarra - Nefrología

    Pamplona 3114472,
    Spain

    Site Not Available

  • Hospital Universitario Virgen de la Macarena - Nefrología

    Seville,
    Spain

    Active - Recruiting

  • Hospital Universitario Virgen de la Macarena - Nefrología

    Seville 2510911,
    Spain

    Site Not Available

  • University Hospital of Derby and Burton NHS Foundation Trust - Royal Derby Hospital

    Derby,
    United Kingdom

    Active - Recruiting

  • Doncaster and Bassetlaw Hospitals NHS Foundation Trust - Doncaster Royal Infirmary

    Doncaster,
    United Kingdom

    Active - Recruiting

  • Doncaster and Bassetlaw Hospitals NHS Foundation Trust - Doncaster Royal Infirmary

    Doncaster 2651123,
    United Kingdom

    Site Not Available

  • NHS Lothian - Royal Infirmary of Edinburgh

    Edinburgh,
    United Kingdom

    Active - Recruiting

  • NHS Lothian - Royal Infirmary of Edinburgh

    Edinburgh 2650225,
    United Kingdom

    Site Not Available

  • St George's University Hospitals NHS Foundation Trust - St George's Hospital- Renal Medicine

    London,
    United Kingdom

    Active - Recruiting

  • The Royal Wolverhampton NHS Trust - New Cross Hospital

    Wolverhampton,
    United Kingdom

    Active - Recruiting

  • Renal Associates

    Montgomery, Alabama 36117
    United States

    Active - Recruiting

  • Renal Associates

    Montgomery 4076784, Alabama 4829764 36117
    United States

    Site Not Available

  • Southwest Kidney Institute, PLC (SKI) - Surprise

    Surprise, Arizona 85374
    United States

    Active - Recruiting

  • Southwest Kidney Institute, PLC (SKI) - Surprise

    Surprise 5316428, Arizona 5551752 85374
    United States

    Site Not Available

  • Academic Medical Research Institute (AMRI)

    Los Angeles, California 90022
    United States

    Active - Recruiting

  • Valiance Clinical Research - Internal Medicine

    Tarzana, California 91356
    United States

    Active - Recruiting

  • Academic Medical Research Institute (AMRI)

    Los Angeles 5368361, California 5332921 90022
    United States

    Site Not Available

  • Valiance Clinical Research - Internal Medicine

    Tarzana 5401143, California 5332921 91356
    United States

    Site Not Available

  • Western Nephrology & Metabolic Bone Disease PC

    Arvada, Colorado 80002
    United States

    Active - Recruiting

  • Western Nephrology & Metabolic Bone Disease PC

    Arvada 5412199, Colorado 5417618 80002
    United States

    Site Not Available

  • Bioresearch Partner

    Miami, Florida 33127
    United States

    Active - Recruiting

  • CTR Oakwater, LLC

    Orlando, Florida 32806
    United States

    Active - Recruiting

  • Clinical Site Partners, LLC - Orlando

    Winter Park, Florida 32789
    United States

    Active - Recruiting

  • Bioresearch Partner

    Miami 4164138, Florida 4155751 33127
    United States

    Site Not Available

  • CTR Oakwater, LLC

    Orlando 4167147, Florida 4155751 32806
    United States

    Site Not Available

  • Clinical Site Partners, LLC - Orlando

    Winter Park 4178560, Florida 4155751 32789
    United States

    Site Not Available

  • DaVita Clinical Research Columbus

    Columbus, Georgia 31904
    United States

    Active - Recruiting

  • Georgia Nephrology

    Lawrenceville, Georgia 30046
    United States

    Active - Recruiting

  • DaVita Clinical Research Columbus

    Columbus 4188985, Georgia 4197000 31904
    United States

    Site Not Available

  • Georgia Nephrology

    Lawrenceville 4205196, Georgia 4197000 30046
    United States

    Site Not Available

  • CARE Institute-Boise Kidney

    Boise, Idaho 83706
    United States

    Active - Recruiting

  • CARE Institute-Boise Kidney

    Boise 5586437, Idaho 5596512 83706
    United States

    Site Not Available

  • NANI Research

    Hinsdale, Illinois 60521
    United States

    Active - Recruiting

  • NANI Research

    Hinsdale 4896012, Illinois 4896861 60521
    United States

    Site Not Available

  • DaVita Clinical Research Houston

    Indianapolis 4259418, Indiana 4921868 46214-2985
    United States

    Site Not Available

  • DaVita Clinical Research Edina

    Edina, Minnesota 55435
    United States

    Active - Recruiting

  • DaVita Clinical Research Edina

    Edina 5025264, Minnesota 5037779 55435
    United States

    Site Not Available

  • Kidney Specialists of Southern Nevada

    Las Vegas, Nevada 89107
    United States

    Active - Recruiting

  • Kidney Specialists of Southern Nevada

    Las Vegas 5506956, Nevada 5509151 89107
    United States

    Site Not Available

  • Carolina Nephrology Greenville

    Greenville, South Carolina 29605
    United States

    Active - Recruiting

  • Carolina Nephrology, PA

    Spartanburg, South Carolina 29306
    United States

    Active - Recruiting

  • Carolina Nephrology Greenville

    Greenville 4580543, South Carolina 4597040 29605
    United States

    Site Not Available

  • Carolina Nephrology, PA

    Spartanburg 4597200, South Carolina 4597040 29306
    United States

    Site Not Available

  • El Paso Kidney Specialists

    El Paso, Texas 79902
    United States

    Active - Recruiting

  • DaVita Clinical Research Houston

    Houston, Texas 77054
    United States

    Active - Recruiting

  • Provecta Research Network

    Houston, Texas 77027
    United States

    Active - Recruiting

  • Davita Clinical Research San Antonio

    San Antonio, Texas 78251
    United States

    Active - Recruiting

  • El Paso Kidney Specialists

    El Paso 5520993, Texas 4736286 79902
    United States

    Site Not Available

  • DaVita Clinical Research Houston

    Houston 4699066, Texas 4736286 77054
    United States

    Site Not Available

  • Provecta Research Network

    Houston 4699066, Texas 4736286 77027
    United States

    Active - Recruiting

  • Davita Clinical Research San Antonio

    San Antonio 4726206, Texas 4736286 78251
    United States

    Site Not Available

  • Utah Kidney Research

    Salt Lake City, Utah 84115
    United States

    Active - Recruiting

  • Utah Kidney Research

    Salt Lake City 5780993, Utah 5549030 84115
    United States

    Site Not Available

  • Milwaukee Neprologists, SC

    Wauwatosa, Wisconsin 53226
    United States

    Active - Recruiting

  • Milwaukee Neprologists, SC

    Wauwatosa 5278159, Wisconsin 5279468 53226
    United States

    Site Not Available

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