Phase
Condition
Alzheimer's Disease
Mild Cognitive Impairment
Memory Loss
Treatment
Transcranial Magnetic Stimulation
Clinical Study ID
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Individuals with mild cognitive impairment (MCI Group)
Inclusion Criteria:
Age 18-85 years
MCI subjective criteria: self- or informant-reported cognitive complaint
Objective cognitive impairment supported by one of the following measures of generalcognitive function: (a) classified as MCI via the NACC-UDS 3.0 neuropsychologicalbattery using the typical neuropsychological criteria for MCI diagnosis (1 score onany test at least1.5 SD below the mean); or (b) classified as MCI via the NACC-UDS 3.0 neuropsychological battery using the Jak/Bondi neuropsychological criteria forMCI diagnosis(2 scores at least 1 SD below the mean in one domain, or 3 scores atleast 1SD below the mean across domains)
Right-handed
English speaking
Able to attend daily intervention and outcome measurements for ~15 days over a 6month period.
Not enrolled in another interventional study within 6 months prior to beginning thisstudy
Exclusion
Exclusion Criteria:
Contraindications to transcranial magnetic stimulation (TMS) or magnetic resonanceimaging (MRI)
Reported sudden or steep decline of cognitive performance
Telephone Interview for cognitive impairment (TICS) score
Other neurological disorders (e.g., stroke, head injuries, or multiple sclerosis)
Psychiatric disorder (except stable late-life depression due to its high prevalencein MCI individuals)
Current cancer treatment or other comorbid/unstable medical conditions that mightindependently affect cognitive function