Quantitative Ultrasound(DeepUSFF) vs MRI-PDFF for Liver Fat Assessment in MASLD

Inclusion Criteria:

• Patients with clinically suspected MASLD based on abnormal ultrasound or liverfunction tests requiring liver ultrasound or MRI examination

• BMI ≥25 kg/m² or waist circumference >90 cm (male) or >80 cm (female), suggestinghigh likelihood of fatty liver disease

• Living liver transplant donors requiring preoperative liver ultrasound or MRIexamination

• Age ≥18 years

• Understanding and signing informed consent

Exclusion Criteria:

• Significant alcohol consumption in the past 2 years:

Male: ≥30-60g/day average alcohol intake Female: ≥20-50g/day average alcohol intake

-Chronic liver disease:

Histological diagnosis of chronic liver disease HBsAg positive Anti-HCV positive Other suspected chronic liver diseases

-Liver failure:

Serum albumin <3.2 g/dL INR >1.3 Direct bilirubin >1.3 mg/dL

• History of esophageal varices, ascites, hepatic encephalopathy, or acute biliaryobstruction

• History of liver cancer diagnosis or treatment

• History of liver surgery

• Pregnancy

• Inability to obtain adequate liver ultrasound imaging:

Patient cooperation impossible Inadequate image acquisition as determined by investigator

-Inability to obtain adequate liver MRI imaging: Patient cooperation impossible Severe obesity preventing MRI examination MRI contraindications (cardiac pacemaker, etc.) Other factors preventing adequate imaging as determined by investigator