A Study to Evaluate the Safety and Effectiveness of JUVÉDERM Products in Adult Participants for the Change of Their Overall Facial Appearance

Last updated: February 20, 2026
Sponsor: AbbVie
Overall Status: Active - Not Recruiting

Phase

4

Condition

N/A

Treatment

JUVÉDERM VOLBELLA XC

JUVÉDERM ULTRA PLUS XC

SKINVIVE by JUVÉDERM

Clinical Study ID

NCT07186595
M25-631
  • Ages 22-65
  • All Genders

Study Summary

The purpose of this study is to evaluate the safety and effectiveness of JUVÉDERM products in adults seeking improvement in facial volume and/or skin quality.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Must meet at least 3 of the following criteria for treatment in the face with atleast 2 JUVÉDERM products, per investigator's assessment:

  • Minimal, moderate, or severe on Allergan Temple Hollowing Scale (ATHS)

  • Moderate or severe for both eyes on Allergan Infraorbital Hollow Scale (AIHS)

  • Moderate or severe on Allergan Cheek Smoothness Scale (ACSS)

  • Moderate, significant, or severe on Mid-face Volume Deficit Scale (MFVDS)

  • Moderate or severe on Nasolabial Fold Severity Scale (NLFSS)

  • Minimal, mild, or moderate on Allergan Lip Fullness Scale 2 (ALFS2)

  • Moderate or severe on Allergan Chin Retrusion Scale (ACRS)

  • Moderate or severe on Allergan Loss of Jawline Definition Scale (ALJDS)

  • Must be in good health as determined by subject's medical history, physicalexamination, and vital sign measurements.

Exclusion

Exclusion Criteria:

  • Prior treatment with non-permanent soft tissue fillers or fat-reducing injectablesin the face or neck within 12 months prior to screening.

  • Excessively loose skin in the face and/or neck.

  • Tendency to develop hypertrophic scarring and/or keloid scarring.

Study Design

Total Participants: 75
Treatment Group(s): 7
Primary Treatment: JUVÉDERM VOLBELLA XC
Phase: 4
Study Start date:
September 25, 2025
Estimated Completion Date:
August 31, 2026

Connect with a study center

  • Kian Aesthetic Institute /ID# 277045

    Los Angeles 5368361, California 5332921 90025
    United States

    Site Not Available

  • West Dermatology La Jolla /ID# 277034

    San Diego 5391811, California 5332921 92121
    United States

    Site Not Available

  • Pacific Clinical Innovations /ID# 277026

    Vista 5406602, California 5332921 92083
    United States

    Site Not Available

  • Skin Research Institute LLC /ID# 277038

    Coral Gables 4151871, Florida 4155751 33146-1837
    United States

    Site Not Available

  • Monarch Plastic Surgery and Skin Renewal Center /ID# 278182

    Atlanta 4180439, Georgia 4197000 30328
    United States

    Site Not Available

  • Advanced Dermatology - Lincolnshire /ID# 277036

    Lincolnshire 4899983, Illinois 4896861 60069
    United States

    Site Not Available

  • H&H Research, LLC /ID# 277084

    Metairie 4333177, Louisiana 4331987 70001
    United States

    Site Not Available

  • DelRicht Research - New Orleans 308 /ID# 277039

    New Orleans 4335045, Louisiana 4331987 70115
    United States

    Site Not Available

  • Bellaire Dermatology Associates /ID# 278180

    Bellaire 4673353, Texas 4736286 77401
    United States

    Site Not Available

  • SkinDC /ID# 277062

    Arlington 4744709, Virginia 6254928 22209
    United States

    Site Not Available

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