Aleniglipron Phase 2 Body Composition Study

Inclusion Criteria:

• Signed informed consent

• Participants age ≥18 years and <80 years, with BMI ≥30 kg/m2

• Screening HbA1c <6.5 %

Exclusion Criteria:

• Previous documented diagnosis of diabetes mellitus

• Self-reported change in body weight >5% within 3 months before Screening

• Have a body weight, height, and/or width that prohibits the ability to obtainaccurate measurements according to the DXA study specific manual that allowshemi-scan

• Have a prior or planned surgical treatment for obesity (excluding liposuction orabdominoplasty, if performed >1 year prior to screening)

• Have obesity induced by other endocrine disorders (such as Cushing's syndrome,Prader-Willi syndrome, or melanocortin 4 receptor deficiency)