Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults With Primary Open Angle Glaucoma or Ocular Hypertension

Last updated: May 5, 2026
Sponsor: Bausch & Lomb Incorporated
Overall Status: Active - Not Recruiting

Phase

2

Condition

Glaucoma

Treatment

BL1107 High dose

Timolol maleate 0.5%

BL1107 Low dose

Clinical Study ID

NCT07168902
RX01-BL1107-1201
  • Ages > 18
  • All Genders

Study Summary

Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults with Primary Open Angle Glaucoma or Ocular Hypertension

Eligibility Criteria

Inclusion

Inclusion criteria:

  • Ocular hypertension or primary open-angle glaucoma in each eye

Exclusion

Exclusion criteria:

  • History of orthostatic hypotension

  • Any active ocular disease

  • Anticipated wearing of contact lenses during study

  • Contraindication to pupil dilation

Study Design

Total Participants: 252
Treatment Group(s): 3
Primary Treatment: BL1107 High dose
Phase: 2
Study Start date:
October 24, 2025
Estimated Completion Date:
May 31, 2026

Study Description

This study will evaluate the safety and efficacy of BL1107 in adults with primary open-angle glaucoma or ocular hypertension in both eyes. This is a randomized, double-masked, parallel comparison to evaluate two concentrations of BL1107 in both eyes compared with timolol 0.5% for 28 days.

Connect with a study center

  • Global Research Management, Inc.

    Glendale, California 91204
    United States

    Site Not Available

  • Eye Research Foundation

    Newport Beach, California 92663
    United States

    Site Not Available

  • California Eye Specialist Medical Group, LLC

    Pasadena, California 91107
    United States

    Site Not Available

  • Global Research Management, Inc.

    Glendale 5352423, California 5332921 91204
    United States

    Site Not Available

  • Eye Research Foundation

    Newport Beach 5376890, California 5332921 92663
    United States

    Site Not Available

  • Eye Associates of Fort Myers

    Fort Myers, Florida 33901
    United States

    Site Not Available

  • Levenson Eye Associates

    Jacksonville, Florida 32204
    United States

    Site Not Available

  • Central Florida Eye Associates

    Lakeland, Florida 33805
    United States

    Site Not Available

  • Lee Shettle Eye and Hearing

    Largo, Florida 33773
    United States

    Site Not Available

  • Levenson Eye Associates

    Jacksonville 4160021, Florida 4155751 32204
    United States

    Site Not Available

  • Central Florida Eye Associates

    Lakeland 4161438, Florida 4155751 33805
    United States

    Site Not Available

  • Lee Shettle Eye and Hearing

    Largo 4161580, Florida 4155751 33773
    United States

    Site Not Available

  • Clayton Eye Clinical Research, LLC

    Morrow, Georgia 30260
    United States

    Site Not Available

  • Coastal Research Associates, LLC

    Roswell, Georgia 30076
    United States

    Site Not Available

  • Heart of America Eye Care

    Shawnee Mission, Kansas 66204
    United States

    Site Not Available

  • Andover Eye Associates

    Andover, Massachusetts 01810
    United States

    Site Not Available

  • Andover Eye Associates

    Andover 4929055, Massachusetts 6254926 01810
    United States

    Site Not Available

  • Scott & Christie and Associates, PC

    Cranberry Township, Pennsylvania 16066
    United States

    Site Not Available

  • Scott & Christie and Associates, PC

    Cranberry Township 8643098, Pennsylvania 6254927 16066
    United States

    Site Not Available

  • Total Eye Care, P.A.

    Memphis, Tennessee 38119
    United States

    Site Not Available

  • Total Eye Care, P.A.

    Memphis 4641239, Tennessee 4662168 38119
    United States

    Site Not Available

  • Houston Eye Associates

    Houston, Texas 77025
    United States

    Site Not Available

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