Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

Inclusion Criteria:

• Have Lp(a) ≥175 nanomoles per liter (nmol/L)

• Meet one of the following criteria:

• Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such asheart attack, stroke, or procedure to restore blood flow to the heart or otherparts of the body) within 10 years prior to screening

• Are at risk for a first ASCVD event, defined as one or more of the following:

• Documented coronary artery disease (CAD), carotid stenosis, or peripheralartery disease (PAD) without a history of ASCVD event

• A high coronary artery calcium (CAC) score

• Reduced kidney function with diabetes

• Combination(s) of high risk factors

Exclusion Criteria:

• Have experienced a major cardiovascular event or surgery, such as heart attack,stroke, or procedure to restore blood flow to the heart or other parts of the body,within 90 days prior to screening or occurring between screening and randomization

• Are planning or expected to undergo a procedure to restore blood flow in thearteries or a major heart surgery during the study

• Have uncontrolled high blood pressure

• Have New York Heart Association (NYHA) class III or IV heart failure

• Have undergone a procedure to remove cholesterol from the blood within 90 days ofscreening, or have a planned procedure during the study

• Have severe kidney impairment

• Have had cancer within 5 years prior to screening