A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

Inclusion Criteria:

• Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher atscreening

• Have tried at least once to lose weight through diet but were unsuccessful

• Have osteoarthritis of the knee and at least one of the following conditions:

• Be over 50 years old

• Have morning knee stiffness that lasts about 30 minutes

• Have a crackling or grinding sound or feeling in the knee

Exclusion Criteria:

• Have gained or lost more than 11 pounds within 90 days prior to screening

• Have had a surgery for obesity or plan to have one in the next 18 months

• Have an active knee infection

• Have type 1 diabetes, type 2 diabetes, or any other type of diabetes

• Have had a recent heart condition or New York Heart Association FunctionalClassification Class IV congestive heart failure

• Have used any glucagon-like peptide-1 (GLP-1) receptor agonist medication within 180days of screening