A Study of LY4064912 in Healthy Participants and With Overweight or Obesity

Inclusion Criteria:

• Age is 21-65 years old at Singapore Sites

• Participants who are overtly healthy as determined by medical evaluation includingmedical history, physical examination, laboratory tests, and cardiac monitoring

Part A: Body Mass Index (BMI) within the range greater than or equal to 21 and less than 30 kilogram per square meter (kg/m²)

Part B: a BMI greater than or equal to 27 and less than 45 kg/m²

Part C: a BMI greater than or equal to 21 and less than 35 kg/m²

• Parts A and C: Participants must weigh 60 kilograms (kg) or more at screening

• Have had a less than 5% change in body weight for 3 months before screening

• Safety laboratory tests are within normal reference range

Exclusion Criteria:

• Have a history or presence of cardiovascular, respiratory, hepatic, renal,gastrointestinal, endocrine, hematological, or neurological disorders capable ofsignificantly altering the absorption, metabolism, or elimination of drugs; ofconstituting a risk when taking the investigational product; or of interfering withthe interpretation of data

• Have history of diabetes (except gestational diabetes) or current diagnosis ofdiabetes (any form), or have HbA1c greater than or equal to 6.5% (48 millimole permole (mmol/mol)) at screening

• Are individuals of childbearing potential (IOCBP).