GRANITE: Airsupra Effectiveness in the Real World

Inclusion Criteria:

• Patients with at least one prescription record (based on NDC or healthcare commonprocedure coding system [HCPCS] codes) of Airsupra (for Airsupra arm) or albuterol (for selected albuterol comparator arm) since January 2023

• Patients with an asthma indication (indicated by an ICD-10-CM code J45.xx) withinthe 12 months prior to the index date identified by at least one of the followingHealth Plan Employer Data Information Set (HEDIS) criteria:

At least one IP claim with asthma as the principal admission diagnosis, At least one ED/urgent care claim with asthma as the principal diagnosis, At least four outpatient claims with asthma as one of the listed diagnoses AND at least two claims for any asthma medications (including any rescue or maintenance medications) within the 12 months prior to the index date, At least four prescriptions for any asthma medications within the 12 months prior to the index date;

• Patients with at least one prescription record (based on NDC or HCPCS codes) ofalbuterol within the 12 months prior to the index date

• Patients aged ≥18 years on the index date

• Patients with ≥12 months of continuous insurance enrolment prior to and post indexdate

Exclusion Criteria:

• Patients with at least one medical claim with an ICD-10 code within the 12 monthsprior to the index date for the following chronic respiratory conditions or othersystematic inflammatory diseases routinely treated with SCS: COPD, cystic fibrosis,pulmonary fibrosis, pulmonary arterial hypertension, bronchiectasis, respiratorytract cancer, hypereosinophilic syndrome, Churg-Strauss syndrome, eosinophilicpneumonia, Wegener's granulomatosis, allergic bronchopulmonary aspergillosis,obesity hypoventilation syndrome, hyperventilation syndrome, alpha-1 antitrypsindeficiency, primary ciliary dyskinesia, vasculitis collagen vascular disease,systemic lupus erythematosus, scleroderma, rheumatoid arthritis, Sjogren's syndrome,psoriatic arthritis, or inflammatory bowel disease (ulcerative colitis and Crohn'sdisease)

• Patients with maintenance OCS use within the 12 months prior to the index date,defined as use of OCS covering minimum 50% (6 months) in days' supply

• Airsupra patients with a concomitant SABA prescription record on the index date