European Registry Study on Lymphatic Interventions

Last updated: January 19, 2026
Sponsor: Rigshospitalet, Denmark
Overall Status: Active - Recruiting

Phase

N/A

Condition

Gastrointestinal Diseases And Disorders

Circulation Disorders

Bronchitis

Treatment

Lymphatic intervention

Clinical Study ID

NCT07131293
R-25051744
  • All Genders

Study Summary

This European multicenter observational study aims to evaluate the real-world use, timing, and outcomes of lymphatic interventions in patients with congenital heart disease and/or primary lymphatic disorders. The study will examine the effectiveness of diagnostic imaging and interventional techniques, such as lymphatic embolization, in improving clinical symptoms, biomarkers, and fluid-related complications. The central question is whether early diagnosis and targeted intervention can lead to clinically meaningful improvements and reduced need for reintervention. Data collected retrospectively and prospectively from participating centers will help identify predictors of outcome, assess disease severity, and inform standardized diagnostic and therapeutic pathways across Europe.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients of any age with a confirmed central lymphatic disorder, either in thecontext of CHD or as a primary lymphatic disorder, verified through lymphaticdiagnostics (e.g. lymphatic imaging or relevant biomarkers).

  • Patients who have undergone, or are undergoing, diagnostic lymphatic imaging and/orinterventional procedures for their lymphatic disorder.

  • Patients who are receiving, or have received, conservative (non-interventional)management for their lymphatic disorder.

Exclusion

Exclusion Criteria:

  • Patients with isolated peripheral lymphatic disorders not involving the centrallymphatic system.

  • Patients with acute postoperative iatrogenic chylothorax (<3-4 weeks duration andnot requiring intervention).

  • Patients without sufficient clinical documentation to confirm diagnosis, treatment,or follow-up.

  • Patients who decline, or whose legal guardians decline, to provide informed consent (for prospective inclusion).

Study Design

Total Participants: 500
Treatment Group(s): 1
Primary Treatment: Lymphatic intervention
Phase:
Study Start date:
February 01, 2026
Estimated Completion Date:
March 31, 2030

Study Description

This is a prospective, multicenter observational study with retrospective components. The study population includes patients who have undergone or are undergoing lymphatic imaging diagnostics and lymphatic interventions at participating centers across Europe. Patients are included both retrospectively (from medical records) and prospectively as part of their routine clinical care.

Connect with a study center

  • Rigshospitalet, Copenhagen University Hospital

    Copenhagen, 2100
    Denmark

    Site Not Available

  • Rigshospitalet, Copenhagen University Hospital

    Copenhagen 2618425, 2100
    Denmark

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.