A Study of PHN-012 in Patients With Advanced Solid Tumors

Inclusion Criteria:

• Has histologically confirmed, advanced/metastatic:

1. Colorectal adenocarcinoma (CRC), or

2. Non-small cell lung cancer (NSCLC), or

3. Pancreatic ductal adenocarcinoma (PDAC).

• Has received at least one prior systemic therapy and radiologically or clinicallydetermined progressive disease during or after the most recent line of therapy, andfor whom no further standard therapy is available or who is intolerant to standardtherapy.

• Has measurable disease.

• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

• Has adequate organ function.

• Has available tumor tissue sample at screening (either an archival specimen or freshbiopsy material).

Exclusion Criteria:

• Had prior treatment with any ADC containing topoisomerase-1 inhibiting payload.

• Has unstable central nervous system metastasis.

• Has persistent toxicities from previous systemic anti-cancer treatments of Grade >1.

• Has received systemic anti-neoplastic therapy within five half-lives or 21 days,whichever is shorter, prior to first dose of the study drug.

• Has received wide-field radiotherapy (> 30% of marrow-bearing bones) within 28 days,or focal radiation for analgesic purpose or for lytic lesions at risk of fracturewithin 14 days prior to first dose of the study drug, or no recovery from sideeffects of such intervention.

• Had major surgery (not including placement of vascular access device or tumorbiopsies) within 28 days prior to first dose of the study drug, or no recovery fromside effects of such intervention.

• Has a history of non-infectious pneumonitis (NIP) / interstitial lung disease (ILD)requiring systemic steroids within 6 months prior to first dose of the study drug,active NIP / ILD or suspected NIP / ILD which cannot be ruled out by imaging forScreening.