A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in the United States

Last updated: September 8, 2026
Sponsor: Merz North America, Inc.
Overall Status: Active - Not Recruiting

Phase

3

Condition

N/A

Treatment

NT 201 Placebo

NT 201

Clinical Study ID

NCT07122193
NT-PPR-US001
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to assess the safety and efficacy of NT 201 compared with placebo in participants with moderate to severe platysma prominence. The study will be conducted in two periods: Main Period (MP) and Open label Extension Period (OLEX).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Presence of four (medial and lateral, left and right) platysmal bands assessed atscreening and baseline.

  • A score of Grade 3 ('moderate') or Grade 4 ('severe') on the MAPS-D at maximumcontraction by the investigator and participant.

Exclusion

Exclusion Criteria:

  • Hypersensitivity or a history of allergic reaction to botulinum toxin of anyserotype or any of their formulation ingredients.

  • Any medical condition that may put the participant at increased risk with exposureto botulinum toxin of any serotype, or any disorders that might interfere withneuromuscular function.

  • Any serious disease or disorder that could interfere with the safe completion oftreatment or with study outcome assessments, or compromise participant safety.

  • Botulinum toxin treatment in the face (below the lower orbital rim), jawline, orneck within the last seven months.

  • History of lower face surgery, neck or chest surgery, and aesthetic procedures inthe past 12 months, and/or orthodontic procedures in the past 6 months.

  • Planned surgery or aesthetic procedures to the lower face, neck, or chest during thestudy period.

  • Anticipated need for treatment with botulinum toxin of any serotype for anyindication during the study (other than study products).

Study Design

Total Participants: 300
Treatment Group(s): 2
Primary Treatment: NT 201 Placebo
Phase: 3
Study Start date:
August 27, 2025
Estimated Completion Date:
September 30, 2027

Connect with a study center

  • Merz Investigative Site

    San Juan, 00917
    Puerto Rico

    Site Not Available

  • Merz Investigative Site

    Scottsdale, Arizona 85260
    United States

    Site Not Available

  • Merz Investigative Site

    Encino, California 91436
    United States

    Site Not Available

  • Merz Investigative Site

    Los Angeles, California 90069
    United States

    Site Not Available

  • Merz Investigative Site

    Redondo Beach, California 90277
    United States

    Site Not Available

  • Merz Investigative Site

    Santa Monica, California 90404
    United States

    Site Not Available

  • Merz Investigative Site

    Vista, California 92803
    United States

    Site Not Available

  • Merz Investigative Site

    Greenwood Village, Colorado 80111
    United States

    Site Not Available

  • Merz Investigative Site

    Westport, Connecticut 06880
    United States

    Site Not Available

  • Merz Investigative Site

    Washington D.C., District of Columbia 20037
    United States

    Site Not Available

  • Merz Investigative Site

    Aventura, Florida 33180
    United States

    Site Not Available

  • Merz Investigative Site

    Boca Raton, Florida 33431
    United States

    Site Not Available

  • Merz Investigative Site

    Bradenton, Florida 34209
    United States

    Site Not Available

  • Merz Investigative Site

    Coral Gables, Florida 33143
    United States

    Site Not Available

  • Merz Investigative Site

    West Palm Beach, Florida 33404
    United States

    Site Not Available

  • Merz Investigative Site

    Coral Gables 4151871, Florida 4155751 33146
    United States

    Active - Recruiting

  • Merz Investigative Site

    Alpharetta, Georgia 30005
    United States

    Site Not Available

  • Merz Investigative Site

    Naperville, Illinois 60563
    United States

    Site Not Available

  • Merz Investigative Site

    Hunt Valley, Maryland 21030
    United States

    Site Not Available

  • Merz Investigative Site

    Mount Kisco, New York 10549
    United States

    Site Not Available

  • Merz Investigative Site

    New York, New York 10021
    United States

    Site Not Available

  • Merz Investigative Site

    New York 5128581, New York 5128638 10028
    United States

    Active - Recruiting

  • Merz Investigative Site

    Chapel Hill, North Carolina 27517
    United States

    Site Not Available

  • Merz Investigative Site

    Wilmington, North Carolina 28405
    United States

    Site Not Available

  • Merz Investigative Site

    Ardmore, Pennsylvania 19003
    United States

    Site Not Available

  • Merz Investigative Site

    Nashville, Tennessee 37215
    United States

    Site Not Available

  • Merz Investigative Site

    Dallas, Texas 75225
    United States

    Site Not Available

  • Merz Investigative Site

    Arlington, Virginia 22209
    United States

    Site Not Available

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