NB02(POSELTINIB) Monotherapy in R/R Non-Hodgkin's Lymphoma

Inclusion Criteria:

1. Age 19 to 80 years.

2. Patients must voluntarily agree to participate in the study and provide writteninformed consent prior to any study-related procedures.

3. Patients with histologically confirmed follicular lymphoma, mantle cell lymphoma ormarginal zone lymphoma.

4. relapsed/refractory Patients who have received more than two prior lines of therapy.

5. Measurable disease based on Lugano classification.

6. Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2.

7. Adequate organ function including:

Exclusion Criteria:

1. Previous treatment with NB02 (poseltinib).

2. Patients who have experienced progression on BTKi mono or BTKi containing regimen (However, patients who discontinued treatment due to adverse-effect-relatedintolerance or for economic or social reasons remain eligible for enrollment).

3. Unable to take oral medication.

4. Inability to comply with study and follow-up procedures.

5. Concurrent use of other investigational drugs or enrollment in another clinicaltrial within 4 weeks prior to study drug administration.

6. Patients who have previously been treated with NB02 (poseltinib) or any other BTKinhibitors (e.g., ibrutinib, acalabrutinib, zanubrutinib).

7. Known HIV, HCV and HBV infection with active diseases