Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)

Inclusion Criteria:

• Age between 24 and 65 years (inclusive)*.

• Confirmed diagnosis of Major Depressive Disorder (MDD), based on MINI interview.

• Hamilton Depression Rating Scale (HDRS-17) score ≥17 at screening.

• On a stable dose of antidepressant medication for at least 30 days prior to HDRS-17screening.

• No evidence of premorbid cognitive impairment, as demonstrated by a standard score >85 on the WRAT-5 Reading Recognition Subtest.

• Confirmed access to a local provider that has primary responsibility for thesubjects' clinical care, and who is available for contact in case of increasedsubject risk due to depressive symptoms.

• Able to provide informed consent and comply with study procedures.

• Access to a quiet space suitable for home-based light stimulation sessions.

• English speaking: All study materials and assessments are only validated in English

Exclusion Criteria:

• Presence of primary neurological or autoimmune disorders.

• Presence of psychiatric comorbidities as determined by the MINI interview (e.g.,anxiety disorders, OCD, PTSD, bipolar disorder, psychotic disorder).

• Current or recent diagnosis of alcohol or substance use disorder.

• History of bipolar disorder or any psychotic disorder.

• Clinically significant suicidal ideation or behavior, based on clinician judgmentand the Columbia-Suicide Severity Rating Scale (C-SSRS).

• History of seizure disorder or epilepsy.

• History of migraine, tinnitus, or photosensitivity.

• Diagnosis of retinal disease, cataract, or other visual impairments that mayinterfere with light exposure.

• Regular use of anti-inflammatory drugs or anticoagulants (e.g., clopidogrel).

• Pregnancy and Breastfeeding: Currently pregnant, planning pregnancy during the studyperiod, or breastfeeding