A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

Last updated: June 15, 2026
Sponsor: Neurocrine Biosciences
Overall Status: Active - Recruiting

Phase

4

Condition

Psychosis

Affective Disorders

Mood Disorders

Treatment

Valbenazine

Clinical Study ID

NCT07105111
NBI-98854-TD4027
  • Ages > 18
  • All Genders

Study Summary

This study will evaluate the efficacy of valbenazine on clinician- and patient-reported outcomes in participants with TD while receiving or after stopping a VMAT2 inhibitor.

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • 18 years of age or older

  • Diagnosed with one of the following at least 3 months prior to screening:schizophrenia or schizoaffective disorder, bipolar disorder, or major depressivedisorder

  • Diagnosed with at least mild neuroleptic-induced TD for at least 3 months prior toscreening

Exclusion

Key Exclusion Criteria:

  • Have comorbid Parkinsonism or abnormal involuntary movement(s) that is moreprominent than TD

  • Diagnosis of moderate or severe substance use disorder in the last 6 months

  • History of long QT syndrome, cardiac arrythmia, or severe hepatic impairment

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: Valbenazine
Phase: 4
Study Start date:
August 29, 2025
Estimated Completion Date:
January 31, 2027

Connect with a study center

  • Neurocrine Clinical Site

    Bryant, Arkansas 72022
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Chino, California 91710
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Fountain Valley, California 92708
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Fresno, California 93701
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Long Beach, California 90807
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Orange, California 92866
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Redlands, California 92373
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    San Diego, California 92123
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Bonita Springs, Florida 34134
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Hialeah, Florida 33012
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Miami, Florida 33144
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Orange City, Florida 32763
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Port Charlotte, Florida 33980
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Tampa, Florida 33629
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Augusta, Georgia 30912
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Marietta, Georgia 30060
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Naperville, Illinois 60563
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Omaha, Nebraska 68124
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Independence, Ohio 44131
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Austin, Texas 78754
    United States

    Active - Recruiting

  • Neurocrine Clinical Site

    Richmond, Virginia 23226
    United States

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.