Study to Assess the Safety and Tolerability of Tafasitamab in Adult Participants With Primary Autoimmune Blood Cell Disorders

Inclusion Criteria:

• Ability to comprehend and willingness to sign a written ICF for the study.

• Aged ≥ 18 years.

• Confirmed historical diagnosis of one of the following autoimmune blood disorders:

• Primary ITP.

• Primary wAIHA.

• No history of splenectomy.

• Confirmed transient response to at least 1 prior early-line treatment (eg,corticosteroids, IVIG, rituximab):

• Primary ITP: Increase in platelet count to ≥ 30 × 109/L with at least a 2-foldincrease of baseline platelet count.

• Primary wAIHA: Increase in hemoglobin to ≥ 10 g/dL with an increase of at least 2 g/dL from baseline.

• Received ≥ 1 standard course of rituximab (375 mg/kg × 4 weekly doses or 2 doses of 1000 mg flat dose every 2 weeks) with last dose given at least 6 months prior toinitiation of study treatment. Note: If rituximab was the only prior therapy,individuals with NR to rituximab will not be eligible.

• Primary ITP: a PR (platelet count ≥ 30 × 109/L with at least a 2-fold increaseof baseline platelet count) within 6 months of the last administered dosefollowed by relapse OR a CR (platelet count > 100 × 109/L) lasting < 48 weeksOR NR (platelet count < 30 × 109/L or less than 2-fold increase of baselineplatelet count or bleeding) within 6 months of the last administered dose.

• Primary wAIHA: a PR with hemoglobin ≥ 10 g/dL and with an increase of at least 2 g/dL from baseline OR a CR (hemoglobin ≥ 12 g/dL and normalization ofhemolytic markers) OR NR (hemoglobin < 10 g/dL or < 2 g/dL increase of baselinehemoglobin).

• Persistent or chronic active primary ITP or active primary wAIHA with indication fortreatment at the time of inclusion.

• Primary ITP: platelet count < 30 × 109/L within the 15 days before treatment isscheduled to begin (Day 1).

Note: Participants treated with a rescue therapy during screening in response to a documented platelet count < 30 × 109/L are eligible, irrespective of platelet count within 15 days of Day 1.

• Primary wAIHA: hemoglobin < 10 g/dL documented with DAT result positive for IgG, with or without C3d, and evidence of hemolysis based on low haptoglobin, elevated LDH, and/or indirect bilirubin.

• ECOG performance status of 0 to 2.

• Willingness to avoid pregnancy or fathering children.

• Further inclusion criteria apply.

Exclusion Criteria:

• Clinical manifestations typical for cold agglutinin disease.

• Life-threatening bleeding or urgent need to elevate the platelet count for primaryITP or hemodynamic instability or hemoglobin < 6 g/dL with urgent need to elevatehemoglobin for primary wAIHA within 2 weeks prior to Day 1.

• Prior treatment with anti-CD19 therapy (eg, mAb, bispecific T-cell engager, or CAR Tcell) for any indication.

• Previous severe allergic reaction to a mAb or known allergy to anycomponent/excipient of tafasitamab.

• Changes in doses (> 10%) of permitted disease-related therapies, including oralcorticosteroids and TPO-RA (primary ITP participants) within 2 weeks prior to Day 1,or change in ESA (primary wAIHA participants) dose within 2 weeks prior to Day 1.

• Evidence of hypogammaglobulinemia during screening (IgA < 70 mg/dL, IgG < 700 mg/dL,and/or IgM < 40 mg/dL) and frequent and/or severe infections.

• Women who are pregnant or breastfeeding.

• History of malignancy except for the following:

• Malignancy treated with curative intent with no evidence of active disease formore than 2 years before screening.

• Adequately treated lentigo maligna melanoma without current evidence of diseaseor adequately controlled nonmelanoma skin cancer.

• Adequately treated carcinoma in situ without current evidence of disease.

• Congestive heart failure (left ventricular ejection fraction of < 50%, assessed by 2dimensional echocardiography or a multigated acquisition scan).

• Participants with:

• Known positive test result for HCV (with HCV antibody serology testing) and apositive test for HCV RNA.

Note: Participants with positive serology must have been tested for HCV RNA and are eligible only in the case of negative HCV RNA test result.

• Known positive test result for chronic HBV infection (defined by HBsAg positivity or positive HBV DNA test result).

Note: Participants with occult or prior HBV infection (defined as negative HBsAg and positive total HBcAb) may be included if HBV DNA was undetectable, provided that they are willing to undergo monthly ongoing DNA testing. Antiviral prophylaxis may be administered as per institutional guidelines.

Note: Participants who have protective titers of HBsAb (HBsAb positive, HBcAb negative, and HBsAg negative) after vaccination or prior HBV infection are eligible.

• Seropositivity for or history of active viral infection with HIV.

• Active systemic infection (including infection with SARS-CoV-2).

• Participants in a severely immunocompromised state, per investigator's clinicalassessment.

• Receipt of a live-attenuated vaccine within 4 weeks prior to the first infusion oftafasitamab (inactivated and killed vaccines are acceptable).

• Coagulation or platelet function abnormality.

• An active medical condition with a strong indication for treatment withanticoagulation agents (eg, intracoronary stent within 12 months).

• Any condition that would, in the investigator's judgment, interfere with fullparticipation in the study, including administration of study treatment andattending required study visits; pose a significant risk to the participant; orinterfere with interpretation of study data.

• Toxicities related to prior therapies must be CTCAE (v5.0) ≤ Grade 1 at the time ofstudy treatment/enrollment (except for chronic toxicities [≤ Grade 2] not expectedto resolve).

• Chronic infectious disease requiring systemic antibiotics or antifungal or antiviralmedications.

• Unwillingness to undergo transfusion with blood components.

• Current use of prohibited medication as described in the protocol.

• Inadequate recovery from toxicity and/or complications from a major surgery beforestarting therapy.

• Further exclusion criteria apply.