VK2735 for Weight Management Phase 3

Inclusion Criteria:

1. Age ≥18 years of age at the time of signing the informed consent

2. Body mass index (BMI) ≥30 kg/m2 OR ≥27 kg/m2 with at least one weight-related co-morbid condition (treated or untreated)

• Weight-related co-morbid conditions include hypertension, dyslipidemia,obstructive sleep apnea or cardiovascular disease

• Cardiovascular disease includes, for example, ischemic cardiovascular disease,New York Heart Association (NYHA) Functional Class I-III heart failure

• BMI calculated at the Screening visit will be used to determine eligibility

Exclusion Criteria:

1. History of or current clinically significant medical disorder that, in the opinionof the Investigator, does not support study participation

2. Self-reported body weight change of 5% or more within 3 months of screening

3. Have a prior or planned surgical treatment for obesity (excluding liposuction orabdominoplasty if performed >1 year prior to screening)

4. Have or plan to have endoscopic and/or device-based therapy for obesity or have haddevice removal within the last 6 months prior to screening (such as, mucosaablation, gastric artery embolization, intragastric balloon, duodenal-jejunalendoluminal line)

5. Current or past diagnosis of diabetes mellitus (including type 1, type 2, exceptgestational diabetes)

6. Treatment with glucose-lowering agent(s) within 90 days before screening

7. Personal or family history of medullary thyroid carcinoma (MTC) or multipleendocrine neoplasia type 2 (MEN2)

8. History of acute or chronic pancreatitis