The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron

Phase

Condition

Allergies & Asthma

Allergy

Treatment

Skin Testing

Clinical Study ID

NCT07103720

25-001858

Ages > 18
All Genders
Accepts Healthy Volunteers

Study Summary

Perioperative anaphylaxis is a potentially life-threatening drug allergic reaction that can occur during anesthetic procedures. The purpose of this research is to determine the maximal nonirritating skin testing concentrations of midazolam, ketamine and ondansetron. These drugs are FDA approved and commonly used before, during and after surgical procedures.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Not have a history of an adverse reactions to midazolam, ketamine or ondansetron
Ability to understand study procedures and to comply with them for the entire lengthof the study.
Contraception is not necessary, and we will include women of reproductivecapability.

Exclusion

Exclusion Criteria:

Unstable patients.
History of any adverse reaction (allergy or sensitivity) to midazolam, ketamine orondansetron.
Pregnant and Pediatric patients
Inability or unwillingness of individual or legal guardian/representative to givewritten informed consent.

Study Design