A Research Study on How a Dose of NNC0662-0419 Works in Japanese, Chinese and Non-Asian Participants Living With Overweight or Obesity

Last updated: August 6, 2025
Sponsor: Novo Nordisk A/S
Overall Status: Active - Recruiting

Phase

1

Condition

Diabetes Prevention

Hypertriglyceridemia

Obesity

Treatment

NNC0662-0419

Clinical Study ID

NCT07101783
NN9662-8159
U1111-1315-2937
  • Ages 18-55
  • All Genders

Study Summary

The study is testing the new medicine NNC0662-0419 in people living with overweight or obesity. The purpose of the study is to look into the amount of the new medicine NNC0662-0419 in participants blood after one dose. And also look into how safe and how well the study medicine is tolerated in people living with overweight or obesity. NNC0662-0419 is a new medicine which cannot be prescribed by doctors. NNC0662-0419 is currently being tested in humans and the dose participants will receive has been found safe and tolerable. Participants will get a single dose of NNC0662-0419 given by study staff as a single injection under participants skin. Like all medicines, the study medicine may have side effects. The study will last up to 2 months.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male or female (sex at birth) Japanese, Chinese or non-Asian participants (allself-reported).

  • For Japanese participants: both parents of Japanese descent.

  • For Chinese participants: both parents of Chinese descent.

  • For non-Asian participants: both parents of non-Asian descent (non-Asian isdefined as of countries outside of Asia).

  • Age 18-55 years (both inclusive) at the time of signing the informed consent.

  • Body mass index (BMI) between 24.0 and 34.9 kilogram per square meter (kg/m^2) (bothinclusive) at screening. Overweight should be due to excess adipose tissue, asjudged by the investigator.

  • Considered eligible based on the medical history, physical examination, and theresults of vital signs, electrocardiogram and clinical laboratory tests performedduring the screening visit, as judged by the investigator.

Exclusion

Exclusion Criteria:

  • Known a* or suspected hypersensitivity to study intervention(s) or related products.

  • Any disorder, unwillingness or inability which in the investigator's opinion, mightjeopardise the participant's safety or compliance with the protocol.

  • 2nd or 3rd degree atrioventricular-block, prolongation of the QRS complex over 120millisecond (msec), or of the corrected QT interval by Fridericia (QTcF) calculationover 450 msec (females) or 430 msec (males), or any other clinically significantabnormal electrocardiogram (ECG) results as judged by the investigator, atscreening.

  • Glycated haemoglobin (HbA1c) greater than or equal to >= 6.5percent (%) (48millimoles per liter [mmol/mol]) at screening.

  • Calcitonin >= 50 nanogram per liter (ng/L) at screening. a* - As declared by theparticipant or reported in the medical records.

Study Design

Total Participants: 99
Treatment Group(s): 1
Primary Treatment: NNC0662-0419
Phase: 1
Study Start date:
August 01, 2025
Estimated Completion Date:
November 02, 2025

Connect with a study center

  • Altasciences Clinical LA, Inc.

    Cypress, California 90630
    United States

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.