Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

Last updated: February 25, 2026
Sponsor: Vanda Pharmaceuticals
Overall Status: Active - Recruiting

Phase

2

Condition

Vascular Diseases

Stress

Circulation Disorders

Treatment

iloperidone

Placebo

Clinical Study ID

NCT07090161
VP-VYV-683-2401
  • Ages 18-65
  • All Genders

Study Summary

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants with Uncontrolled Hypertension

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • SiSBP >/= 130 mmHg despite >8 weeks treatment w/ 1 or more antihypertensivetherapies

Exclusion

Exclusion Criteria:

  • Confirmed Grade 3/severe hypertension (SiSBP >/= 180 mmHg, SiDBP >/= 120 mmHg),unstable cardiac disease, renal insufficiency

Study Design

Total Participants: 240
Treatment Group(s): 2
Primary Treatment: iloperidone
Phase: 2
Study Start date:
September 15, 2025
Estimated Completion Date:
November 30, 2026

Connect with a study center

  • Vanda Investigative Site

    Phoenix 5308655, Arizona 5551752 85053
    United States

    Site Not Available

  • Vanda Investigative Site

    Tempe 5317058, Arizona 5551752 85281
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Tucson 5318313, Arizona 5551752 85715
    United States

    Site Not Available

  • Vanda Investigative Site

    Chula Vista 5336899, California 5332921 91910
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Dublin 5344157, California 5332921 94568
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Valencia 5405288, California 5332921 91355
    United States

    Site Not Available

  • Vanda Investigative Site

    Walnut Creek 5406990, California 5332921 94596
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Doral 4153471, Florida 4155751 33172
    United States

    Site Not Available

  • Vanda Investigative Site

    Fort Myers 4155995, Florida 4155751 33912
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Columbus 4188985, Georgia 4197000 31904
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Oak Brook 4904277, Illinois 4896861 60523
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Tinley Park 4913723, Illinois 4896861 60477
    United States

    Active - Recruiting

  • Vanda Investigative Site

    El Dorado 4270863, Kansas 4273857 67042
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Wichita 4281730, Kansas 4273857 67226
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Lexington 4297983, Kentucky 6254925 40509
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Hazelwood 4389967, Missouri 4398678 63042
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Las Vegas 5506956, Nevada 5509151 89119
    United States

    Site Not Available

  • Vanda Investigative Site

    Mount Kisco 5127744, New York 5128638 10549
    United States

    Site Not Available

  • Vanda Investigative Site

    Rochester 5134086, New York 5128638 14609
    United States

    Site Not Available

  • Vanda Investigative Site

    Kinston 4474436, North Carolina 4482348 28501
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Cincinnati 4508722, Ohio 5165418 45212
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Norman 4543762, Oklahoma 4544379 73069
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Oklahoma City 4544349, Oklahoma 4544379 73112
    United States

    Site Not Available

  • Vanda Investigative Site

    Charleston 4574324, South Carolina 4597040 29414
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Carrollton 4679195, Texas 4736286 75006
    United States

    Site Not Available

  • Vanda Investigative Site

    Salt Lake City 5780993, Utah 5549030 84124
    United States

    Site Not Available

  • Vanda Investigative Site

    Burke 4749950, Virginia 6254928 22015
    United States

    Active - Recruiting

  • Vanda Investigative Site

    Norfolk 4776222, Virginia 6254928 23502
    United States

    Active - Recruiting

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