PERceptions of Diltiazem Versus ADEnosine for Treatment of Supraventricular Tachycardia in the Emergency Department

Last updated: May 26, 2026
Sponsor: University of Iowa
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Defect

Fast Heart Rate (Tachycardia)

Cardiac Disease

Treatment

IV diltiazem

IV adenosine

Clinical Study ID

NCT07086560
202411431
  • Ages 18-100
  • All Genders

Study Summary

Supraventricular tachycardia (SVT) is a dysrhythmia characterized rapid heart rate, typically with rapid onset. SVT accounts for over 50,000 emergency department visits per year. Of patients with regular, narrow-complex SVT, the mainstay of therapy includes adenosine and diltiazem. Adenosine is recommend by American and European guidelines as first-line therapy, however adenosine carries unique side effects that are potentially distressing to patients, including: "feeling of impending death or doom", flushing, anxiety, shortness of breath, and chest discomfort. Diltiazem does not carry this side effect profile, but has typically been reserved as second-line treatment due to side effects of low blood pressure associated with this class of medications. Diltiazem and adenosine have not been well studied head-to-head to compare safety and efficacy of their treatment for SVT. The purpose of this study is to evaluate safety and efficacy of adenosine and diltiazem for SVT in the ED (as completed through chart review of specific patient-level outcomes) and capture patient and clinician perspectives of medication satisfaction (through administration of questionnaires).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. ED encounter for acute SVT

  2. Age >/= 18 years

  3. Receipt of IV adenosine and/or IV diltiazem for SVT in the ED or prehospital setting

Exclusion

Exclusion Criteria:

  1. Neurologic status precluding survey participation due to medical instability

  2. Pregnant

  3. Incarcerated

  4. Non-English speaking

Study Design

Total Participants: 20
Treatment Group(s): 2
Primary Treatment: IV diltiazem
Phase:
Study Start date:
April 04, 2025
Estimated Completion Date:
December 31, 2027

Connect with a study center

  • University of Iowa Health Care

    Iowa City, Iowa 52242
    United States

    Active - Recruiting

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