Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy

Last updated: January 5, 2026
Sponsor: Mayo Clinic
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Aneurysm

Treatment

Observation

Clinical Study ID

NCT07086183
25-006605
  • Ages > 18
  • All Genders

Study Summary

This study is looking at how taking aspirin regularly affects bleeding during and after brain surgery. Specifically, it focuses on patients who are having elective surgery to clip a brain aneurysm.

Aspirin is commonly used to prevent heart attacks and strokes, but it can also increase the risk of bleeding. Doctors often face a tough decision: should patients stop taking aspirin before surgery to reduce bleeding risk, or continue it to prevent blood clots?

To help answer this question, researchers will observe 100 patients, some who take aspirin regularly and some who don't, at hospitals in the U.S., Russia, and Italy. They will not change any treatments but will collect information about bleeding during surgery, blood test results, and CT scans after surgery.

The goal is to better understand the risks of continuing aspirin and to help doctors make safer decisions for future patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age > or = 18 years old

  • Patients willing to participate and provide an informed consent

  • Patients undergoing elective craniotomy for cerebral aneurysm clipping

  • Patients on chronic low-dose (75-100 mg) aspirin daily (aspirin group) or not onaspirin therapy for at least 7 days (control group) preoperatively.

Exclusion

Exclusion Criteria:

  • Emergency craniotomy

  • Use of other antiplatelet or anticoagulant medications within 7 days prior tosurgery

  • Known bleeding disorders (e.g. hemophilia, thrombocytopenia)

  • History of intracranial hemorrhage unrelated to aneurysm

  • Inability to provide informed consent

Study Design

Total Participants: 100
Treatment Group(s): 1
Primary Treatment: Observation
Phase:
Study Start date:
December 01, 2026
Estimated Completion Date:
December 01, 2027

Connect with a study center

  • Sapienza University of Rome

    Roma, 00185
    Italy

    Site Not Available

  • Sapienza University of Rome

    Roma 8957247, 00185
    Italy

    Site Not Available

  • Burdenko National Medical Research Center of Neurosurgery

    Moscow 524901, 125047
    Russia

    Site Not Available

  • Burdenko National Medical Research Center of Neurosurgery

    Moscow, 125047
    Russian Federation

    Site Not Available

  • Mayo Clinic Florida

    Jacksonville, Florida 32224
    United States

    Site Not Available

  • Mayo Clinic Florida

    Jacksonville 4160021, Florida 4155751 32224
    United States

    Site Not Available

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