Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction

Key Inclusion Criteria:

• Diagnosis of open-angle glaucoma or ocular hypertension in both eyes;

• Unmedicated intraocular pressure measurements in the study eye as specified in theprotocol;

• Corrected distance visual acuity equal to or better than 20/100 in the study eye.

Key Exclusion Criteria:

• Current use of more than 2 ocular hypotensive medications within 30 days;

• Intraocular pressure greater than 36 millimeters mercury (mmHg) at Screening;

• Use of topical ocular medication of any kind within 5 days of Screening orthroughout the study with the exception of ocular hypotensive medications (must bewashed out).