Symplicity China Study

Inclusion Criteria:

1. Aged 18 years or older.

2. Patients diagnosed with resistant hypertension or antihypertensive drug intoleranceand treated with Symplicity Spyral Renal Denervation System. Resistant hypertension,defined as having an office systolic blood pressure (SBP) ≥140 mmHg despiteappropriate lifestyle measures and being treated with three or more antihypertensivemedications (including a diuretic) for more than 3 months; or drug intolerance,defined as patients who cannot tolerate medication due to contraindications oradverse effects.

3. The patient voluntarily undergoes renal denervation; the patient has been informedof the observational nature of the study; the patient voluntarily provides writteninformed consent ("Patient Informed Consent Form") and willingly participates in thestudy.

Exclusion Criteria:

1. At least one main renal artery with a diameter less than 3 mm or greater than 8 mm.

2. Presence of fibromuscular dysplasia.

3. Renal artery stent placement within 3 months prior to the procedure.

4. Presence of Renal artery aneurysms.

5. Presence of more than 50% stenosis in any treatable vessel.

6. Pregnant.

7. Present of renal or adrenal tumors.

8. Iliac/femoral artery stenosis prevents catheter insertion.